F
Frédérique Tissier
Researcher at Pierre-and-Marie-Curie University
Publications - 120
Citations - 7977
Frédérique Tissier is an academic researcher from Pierre-and-Marie-Curie University. The author has contributed to research in topics: Adrenocortical carcinoma & Germline mutation. The author has an hindex of 40, co-authored 120 publications receiving 7045 citations. Previous affiliations of Frédérique Tissier include French Institute of Health and Medical Research & University of Paris.
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Journal ArticleDOI
SDHA is a tumor suppressor gene causing paraganglioma
Nelly Burnichon,J. Brière,Rossella Libé,Laure Vescovo,Julie Rivière,Julie Rivière,Frédérique Tissier,Elodie Jouanno,Xavier Jeunemaitre,Xavier Jeunemaitre,Paule Bénit,Alexander Tzagoloff,Pierre Rustin,Jérôme Bertherat,Judith Favier,Judith Favier,Anne-Paule Gimenez-Roqueplo +16 more
TL;DR: In vivo and in vitro functional studies demonstrated that the SDHA mutation causes a loss of SDH enzymatic activity in tumor tissue and in the yeast model, and should be considered as a new paraganglioma/pheochromocytoma susceptibility gene.
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Integrated genomic characterization of adrenocortical carcinoma
Guillaume Assié,Eric Letouzé,Martin Fassnacht,Anne Jouinot,W. Luscap,Olivia Barreau,H. Omeiri,S. Rodriguez,Karine Perlemoine,Fernande René-Corail,Nabila Elarouci,Silviu Sbiera,Matthias Kroiss,Bruno Allolio,Jens Waldmann,Marcus Quinkler,Massimo Mannelli,Franco Mantero,Thomas G. Papathomas,Ronald R. de Krijger,Antoine Tabarin,Véronique Kerlan,Eric Baudin,Frédérique Tissier,Bertrand Dousset,Lionel Groussin,Laurence Amar,Eric Clauser,Xavier Bertagna,Bruno Ragazzon,Felix Beuschlein,Rossella Libé,Aurélien de Reyniès,Jérôme Bertherat +33 more
TL;DR: Aggressive and indolent ACCs correspond to two distinct molecular entities driven by different oncogenic alterations, which are validated in an independent cohort of 77 ACCs.
Journal ArticleDOI
An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis.
Francien H van Nederveen,José Gaal,Judith Favier,Esther Korpershoek,Rogier A. Oldenburg,Elly M C A de Bruyn,Hein F.B.M. Sleddens,Pieter Derkx,Julie Rivière,Hilde Dannenberg,Bart-Jeroen Petri,Paul Komminoth,Karel Pacak,Wim C. J. Hop,Patrick J. Pollard,Massimo Mannelli,Jean-Pierre Bayley,Aurel Perren,Stephan Niemann,Albert A.J. Verhofstad,Adriaan P. de Bruïne,Eamonn R. Maher,Frédérique Tissier,Tchao Meatchi,Cécile Badoual,Jérôme Bertherat,Laurence Amar,Despoina Alataki,Eric Van Marck,Francesco Ferraù,Jerney François,Wouter W. de Herder,Mark-Paul F M Vrancken Peeters,Anne van Linge,Jacques W.M. Lenders,Jacques W.M. Lenders,Anne-Paule Gimenez-Roqueplo,Ronald R. de Krijger,Winand N.M. Dinjens +38 more
TL;DR: Phaeochromocytoma-paraganglioma syndrome can be diagnosed reliably by an immunohistochemical procedure and SDHB immunohistsochemistry could improve the diagnosis, according to a large retrospective and prospective tumour series.
Journal ArticleDOI
Mutations of β-Catenin in Adrenocortical Tumors: Activation of the Wnt Signaling Pathway Is a Frequent Event in both Benign and Malignant Adrenocortical Tumors
Frédérique Tissier,Catherine Cavard,Lionel Groussin,Karine Perlemoine,Gwladys Fumey,Anne-Marie Hagnere,Fernande René-Corail,E. Jullian,Christine Gicquel,Xavier Bertagna,Marie-Cécile Vacher-Lavenu,Christine Perret,Jérôme Bertherat +12 more
TL;DR: Functional studies showed that the activating Ser45 beta-catenin mutation found in the adrenocortical cancer H295R cell line leads to constitutive activation of T-cell factor-dependent transcription, the first molecular defect to be reported with the same prevalence in both benign and malignant adrenOCortical tumors.
Journal ArticleDOI
Clinical and biological features in the prognosis of adrenocortical cancer: poor outcome of cortisol-secreting tumors in a series of 202 consecutive patients.
Gwenaelle Abiven,Joël Coste,Lionel Groussin,Philippe Anract,Frédérique Tissier,Paul Legmann,Bertrand Dousset,Xavier Bertagna,Jérôme Bertherat +8 more
TL;DR: This study highlights the better prognosis of ACC diagnosed at a noninvasive local stage, the particularly poor prog outlook of patients with cortisol-secreting tumors, and the beneficial effect of o,p'DDD therapy in this subgroup of patients.