G
Guillaume Assié
Researcher at University of Paris
Publications - 139
Citations - 7596
Guillaume Assié is an academic researcher from University of Paris. The author has contributed to research in topics: Medicine & Adrenocortical carcinoma. The author has an hindex of 40, co-authored 105 publications receiving 6015 citations. Previous affiliations of Guillaume Assié include Paris Descartes University & French Institute of Health and Medical Research.
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Journal ArticleDOI
Integrated genomic characterization of adrenocortical carcinoma
Guillaume Assié,Eric Letouzé,Martin Fassnacht,Anne Jouinot,W. Luscap,Olivia Barreau,H. Omeiri,S. Rodriguez,Karine Perlemoine,Fernande René-Corail,Nabila Elarouci,Silviu Sbiera,Matthias Kroiss,Bruno Allolio,Jens Waldmann,Marcus Quinkler,Massimo Mannelli,Franco Mantero,Thomas G. Papathomas,Ronald R. de Krijger,Antoine Tabarin,Véronique Kerlan,Eric Baudin,Frédérique Tissier,Bertrand Dousset,Lionel Groussin,Laurence Amar,Eric Clauser,Xavier Bertagna,Bruno Ragazzon,Felix Beuschlein,Rossella Libé,Aurélien de Reyniès,Jérôme Bertherat +33 more
TL;DR: Aggressive and indolent ACCs correspond to two distinct molecular entities driven by different oncogenic alterations, which are validated in an independent cohort of 77 ACCs.
Journal ArticleDOI
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors
Martin Fassnacht,Olaf M. Dekkers,Olaf M. Dekkers,Tobias Else,Eric Baudin,Eric Baudin,Alfredo Berruti,Ronald R. de Krijger,Harm R. Haak,Harm R. Haak,Radu Mihai,Guillaume Assié,Massimo Terzolo +12 more
TL;DR: These guidelines provide clinicians with best possible evidence-based recommendations for clinical management of patients with ACC based on the GRADE system and offer detailed recommendations about the management of mitotane treatment and other supportive therapies.
Journal ArticleDOI
Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma
Siyuan Zheng,Andrew D. Cherniack,Andrew D. Cherniack,Ninad Dewal,Richard A. Moffitt,Ludmila Danilova,Bradley A. Murray,Bradley A. Murray,Antonio M. Lerario,Antonio M. Lerario,Tobias Else,Theo A. Knijnenburg,Giovanni Ciriello,Giovanni Ciriello,Seungchan Kim,Guillaume Assié,Olena Morozova,Rehan Akbani,Juliann Shih,Juliann Shih,Katherine A. Hoadley,Toni K. Choueiri,Toni K. Choueiri,Jens Waldmann,Ozgur Mete,A.G. Robertson,Hsin-Ta Wu,Benjamin J. Raphael,Shao L,Matthew Meyerson,Matthew Meyerson,Michael J. Demeure,Felix Beuschlein,Anthony J. Gill,Anthony J. Gill,Stan B. Sidhu,Stan B. Sidhu,Madson Q. Almeida,Maria Candida Barisson Villares Fragoso,Leslie Cope,Electron Kebebew,Mouhammed Amir Habra,Timothy G. Whitsett,Kimberly J. Bussey,Kimberly J. Bussey,William E. Rainey,Sylvia L. Asa,Jérôme Bertherat,Martin Fassnacht,David A. Wheeler,Gary D. Hammer,Thomas J. Giordano,Roeland Verhaak +52 more
TL;DR: Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers.
Journal ArticleDOI
Clinical and molecular genetics of patients with the Carney-Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD.
Barbara Pasini,Sarah R. McWhinney,Thalia Bei,Ludmila Matyakhina,Sotirios Stergiopoulos,Michael Muchow,Sosipatros Boikos,Barbara Ferrando,Karel Pacak,Guillaume Assié,Guillaume Assié,Eric Baudin,Agnès Chompret,Jay W. Ellison,Jean Jacques Briere,Jean Jacques Briere,Pierre Rustin,Pierre Rustin,Anne Paule Gimenez-Roqueplo,Anne Paule Gimenez-Roqueplo,Charis Eng,Charis Eng,J. Aidan Carney,Constantine A. Stratakis +23 more
TL;DR: It is concluded that succinate dehydrogenase deficiency may be the cause of a subgroup of GISTs and this offers a therapeutic target for Gists that may not respond to STI571 and its analogs.
Journal ArticleDOI
Constitutive Activation of PKA Catalytic Subunit in Adrenal Cushing's Syndrome
Felix Beuschlein,Martin Fassnacht,Guillaume Assié,Davide Calebiro,Constantine A. Stratakis,Andrea Osswald,Cristina L. Ronchi,Thomas Wieland,Silviu Sbiera,Fabio R. Faucz,Katrin Schaak,Anett Schmittfull,Thomas Schwarzmayr,Olivia Barreau,Delphine Vezzosi,Marthe Rizk-Rabin,Ulrike Zabel,Eva Szarek,Paraskevi Salpea,Antonella Forlino,Annalisa Vetro,Orsetta Zuffardi,Caroline Kisker,Susanne Diener,Thomas Meitinger,Martin J. Lohse,Martin Reincke,Jérôme Bertherat,Tim M. Strom,Bruno Allolio +29 more
TL;DR: Genetic alterations of the catalytic subunit of PKA were found to be associated with human disease and Germline duplications of this gene resulted in bilateral adrenal hyperplasias, whereas somatic PRKACA mutations resulted in unilateral cortisol-producing adrenal adenomas.