Thierry Boon

TL;DR: In this paper, a gene was identified that directed the expression of antigen MZ2-E on a human melanoma cell line, which belongs to a family of at least three genes.

TL;DR: It is shown that most human tumors constitutively express IDO, and that expression of IDO by immunogenic mouse tumor cells prevents their rejection by preimmunized mice, suggesting that the efficacy of therapeutic vaccination of cancer patients might be improved by concomitant administration of an IDO inhibitor.

TL;DR: The identification of human tumor rejection antigens opens new possibilities for systematic approaches to the specific immune therapy of cancer.

TL;DR: The cloning of a cDNA is reported that directs the expression of the antigen recognized by HLA-A2 melanoma patients, and this cDNA corresponds to the transcript of the tyrosinase gene.

TL;DR: It appears increasingly unlikely that immunization of patients against one of these antigens will cause harmful immunological side effects caused by the expression of the relevant gene in the testis, and these conclusions are further strengthened by immunization studies carried out with mouse tumor antigen P815A, which is encoded by a gene that is also expressed only in thetestis.