P
Patrick Chomez
Researcher at Ludwig Institute for Cancer Research
Publications - 32
Citations - 6967
Patrick Chomez is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Antigen & Gene. The author has an hindex of 21, co-authored 32 publications receiving 6774 citations. Previous affiliations of Patrick Chomez include Université catholique de Louvain.
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Journal ArticleDOI
A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
P. van der Bruggen,Catia Traversari,Patrick Chomez,Christophe Lurquin,E De Plaen,B Van den Eynde,Alexander Knuth,Thierry Boon +7 more
TL;DR: In this paper, a gene was identified that directed the expression of antigen MZ2-E on a human melanoma cell line, which belongs to a family of at least three genes.
Journal ArticleDOI
A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E.
Catia Traversari,P. van der Bruggen,Immanuel F. Luescher,Christophe Lurquin,Patrick Chomez,A Van Pel,E De Plaen,A Amar-Costesec,Thierry Boon +8 more
TL;DR: It is shown that CTL directed against this antigen, which was named MZ2-E, recognize a nonapeptide encoded by the third exon of gene MAGE-1, which opens the possibility of immunizing HLA-A1 patients whose tumor expresses Mage-1 either with the antigenic peptide or with autologous antigen-presenting cells pulsed with the peptide.
Journal ArticleDOI
Structure, Chromosomal Localization, and Expression of 12 Genes of the Mage Family
Etienne De Plaen,Etienne De Plaen,Catia Traversari,Catia Traversari,José J. Gaforio,José J. Gaforio,Jean-Pierre Szikora,Jean-Pierre Szikora,Charles De Smet,Charles De Smet,Francis Brasseur,Francis Brasseur,Pierre van der Bruggen,Pierre van der Bruggen,Bernard Lethe,Bernard Lethe,Christophe Lurquin,Christophe Lurquin,Patrick Chomez,Patrick Chomez,Olivier De Backer,Olivier De Backer,Thierry Boon,Thierry Boon,Karen C. Arden,Webster K. Cavenee,Robert Brasseur +26 more
TL;DR: Six genes of the MAGE family including MAGE-1 were found to be expressed at a high level in a number of tumors of various histological types and none was expressed in a large panel of healthy tissues, with the exception of testis and placenta.
Journal Article
An Overview of the MAGE Gene Family with the Identification of All Human Members of the Family
Patrick Chomez,Olivier De Backer,Mathieu J.M. Bertrand,Etienne De Plaen,Thierry Boon,Sophie Lucas +5 more
TL;DR: The genomic structure of the MAGE-D genes indicates that one of them corresponds to the founder member of the family, and that all of the other MAGE genes are retrogenes derived from that common ancestral gene.
Journal ArticleDOI
Immunogenic (tum-) variants of mouse tumor P815: cloning of the gene of tum- antigen P91A and identification of the tum- mutation.
E De Plaen,Christophe Lurquin,A Van Pel,B Mariamé,Jean-Pierre Szikora,T. Wölfel,C Sibille,Patrick Chomez,Thierry Boon +8 more
TL;DR: The essential role of this mutation, which produces an amino acid change, was confirmed by site-directed mutagenesis and no significant sequence similarity was found between the 800-base-pair fragment and any recorded gene.