P
Piet Tom Bert Paul Wigerinck
Researcher at Rega Institute for Medical Research
Publications - 36
Citations - 425
Piet Tom Bert Paul Wigerinck is an academic researcher from Rega Institute for Medical Research. The author has contributed to research in topics: Deoxyuridine & Thymidine kinase. The author has an hindex of 9, co-authored 36 publications receiving 417 citations. Previous affiliations of Piet Tom Bert Paul Wigerinck include Tibotec & Galápagos NV.
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Journal ArticleDOI
5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
Piet Tom Bert Paul Wigerinck,Christophe Pannecouque,Robert Snoeck,Paul Claes,E. De Clercq,Piet Herdewijn +5 more
TL;DR: 2'-Deoxyuridines with a five-membered heterocyclic substituent in the 5-position show potent and selective activity against herpes simplex virus type 1 and varicella-zoster virus.
Journal ArticleDOI
Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues
Piet Tom Bert Paul Wigerinck,Luc Kerremans,Paul Claes,Robert Snoeck,P. C. Maudgal,Erik De Clercq,Piet Herdewijn +6 more
TL;DR: introduction of an alkyl substituent in the 5-position of the thienyl group of 5-thien-2-yl-2'-deoxyuridine or substitution of the 2-deoxyribofuranose ring by an arabin ofuranose moiety gave decreased activity against HSV-1 and VZV replication when compared with the 5"-halogenated-5-Thien- 2-yl -2'- deoxyuridines.
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Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
TL;DR: 5-(3-bromoisoxazol-5-yl)-2'-deoxyuridine was inactive against herpes simplex virus type 2, cytomegalovirus, and thymidine kinase (TK)-deficient mutants of HSV-1 and VZV, which indicates that, most likely, its antiviral activity depends on phosphorylation by the virus-specified TK.
Journal ArticleDOI
3′‐(1,2,3‐Triazol‐1‐yl)‐2′,3′‐dideoxythymidine and 3′‐(1,2,3‐triazol‐1‐yl)‐2′,3′‐dideoxyuridine
Piet Tom Bert Paul Wigerinck,Arthur Van Aerschot,Paul Claes,Jan Balzarini,Erik De Clercq,Piet Herdewijn +5 more
TL;DR: In contrast with the parent compounds, these triazolyl derivatives had no appreciable activity against human immunodeficiency virus (HIV-1) as mentioned in this paper, while the parent compound had a 1,2,3 triazol-1-yl substituent in the 3′ position.
Journal ArticleDOI
Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines.
Piet Tom Bert Paul Wigerinck,A. Van Aerschot,Gerard Janssen,Paul Claes,Jan Balzarini,E. De Clercq,Piet Herdewijn +6 more
TL;DR: Various 3'-deoxythymidine analogues with an heterocyclic five-membered ring in the 3'-erythro position have been synthesized and only the pyrrol-1-yl derivative showed marginal antiviral activity against human immunodeficiency virus.