Journal ArticleDOI
3′‐(1,2,3‐Triazol‐1‐yl)‐2′,3′‐dideoxythymidine and 3′‐(1,2,3‐triazol‐1‐yl)‐2′,3′‐dideoxyuridine
Piet Tom Bert Paul Wigerinck,Arthur Van Aerschot,Paul Claes,Jan Balzarini,Erik De Clercq,Piet Herdewijn +5 more
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TLDR
In contrast with the parent compounds, these triazolyl derivatives had no appreciable activity against human immunodeficiency virus (HIV-1) as mentioned in this paper, while the parent compound had a 1,2,3 triazol-1-yl substituent in the 3′ position.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2009-03-12. It has received 45 citations till now.read more
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1,2,3-Triazole and its derivatives. Development of methods for the formation of the triazole ring
TL;DR: In this paper, the synthetic routes to substituted 1,2,3-triazoles, including those containing functional groups, based on cyclisation of various nitrogen compounds published during the last 15 years are described.
Journal ArticleDOI
Synthesis of C-carbamoyl-1,2,3-triazoles by microwave-induced 1,3-dipolar cycloaddition of organic azides to acetylenic amides.
TL;DR: 1,3-Dipolar cycloaddition of organic azides 1, 2, or 3 to acetylenic amides 4 or 5 under solvent-free microwave irradiation produced the corresponding N-substituted C-carbamoyl-1,2, 3-triazoles 7a-12a in good to excellent yields.
Journal ArticleDOI
Synthesis and Antiviral Activities of 1,2,3-triazole Functionalized Thymidines: 1,3-dipolar Cycloaddition for Efficient Regioselective Diversity Generation
Longhu Zhou,Adel Amer,Adel Amer,Michael Korn,Robert Burda,Jan Balzarini,Erik De Clercq,Earl R. Kern,Paul F. Torrence +8 more
TL;DR: 16 novel thymidine analogues were obtained in excellent yields by cycloaddition reaction of azides and alkynes using sodium ascorbate/CuSO4 system as a catalyst, employing mild reaction conditions with a broad scope of structural modification.
References
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Journal ArticleDOI
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).
Françoise Barré-Sinoussi,J. C. Chermann,Félix A. Rey,Marie-Thérèse Nugeyre,S. Chamaret,Jacqueline Gruest,Charles Dauguet,Claudine Axler-Blin,F. Vézinet-Brun,Christine Rouzioux,Willy Rozenbaum,Luc Montagnier +11 more
TL;DR: From these studies it is concluded that this virus as well as the previous HTLV isolates belong to a general family of T-lymphotropic retroviruses that are horizontally transmitted in humans and may be involved in several pathological syndromes, including AIDS.
Journal ArticleDOI
Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS
Robert C. Gallo,Syed Zaki Salahuddin,Mikulas Popovic,Gene M. Shearer,Mark H. Kaplan,Barton F. Haynes,Thomas J. Palker,Robert R. Redfield,James M. Oleske,Bijan Safai,Gilbert C. White,Paul Foster,Phillip D. Markham +12 more
TL;DR: Peripheral blood lymphocytes from patients with the acquired immunodeficiency syndrome (AIDS) or with signs or symptoms that frequently precede AIDS (pre-AIDS) were grown in vitro with added T-cell growth factor and assayed for the expression and release of human T-lymphotropic retroviruses (HTLV).
Journal ArticleDOI
Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides.
Hiroaki Mitsuya,Samuel Broder +1 more
TL;DR: In this paper, the capacity of purine and pyrimidine nucleoside derivatives to inhibit the infectivity and cytopathic effect of human T-lymphotropic virus type III in vitro was tested.
Journal ArticleDOI
Nucleosides. V. The Monomesylates of 1-(2'-Deoxy-β-D-lyxofuranosyl)thymine1,2
Journal ArticleDOI
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.
Piet Herdewijn,Jan Balzarini,E. De Clercq,Rudi Wilfried Jan Pauwels,Masanori Baba,Samuel Broder,H. Vanderhaeghe +6 more
TL;DR: Derivatives from ddThd in which the substituent group was linked to the 3'-carbon atom via a thio, sulfonyl, or oxygen bridge were far less inhibitory to HIV than was AzddThd.