P
Pietro Costa
Researcher at Sapienza University of Rome
Publications - 11
Citations - 355
Pietro Costa is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Congenital hypothyroidism & Newborn screening. The author has an hindex of 5, co-authored 8 publications receiving 316 citations.
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Journal ArticleDOI
Missense Mutation in the Transcription Factor NKX2–5: A Novel Molecular Event in the Pathogenesis of Thyroid Dysgenesis
Monica Dentice,Viviana Cordeddu,Annamaria Rosica,Alfonso Massimiliano Ferrara,Libero Santarpia,Domenico Salvatore,Luca Chiovato,Anna Perri,Lidia Moschini,Cristina Fazzini,Antonella Olivieri,Pietro Costa,Vera Stoppioni,Mariangiola Baserga,Mario De Felice,Mariella Sorcini,Gianfranco Fenzi,Roberto Di Lauro,Marco Tartaglia,Paolo Emidio Macchia +19 more
TL;DR: In this paper, the authors investigated the role of genes involved in both heart and thyroid development in Congenital Hypothyroidism (CH) and found a higher prevalence of CH in children with CH than in the general population.
Journal ArticleDOI
Risk factors for congenital hypothyroidism: results of a population case-control study (1997-2003).
Emanuela Medda,Antonella Olivieri,Maria Antonietta Stazi,Michele E. Grandolfo,Cristina Fazzini,Mariangiola Baserga,Massimo Burroni,Emanuele Cacciari,Francesca Calaciura,Alessandra Cassio,Luca Chiovato,Pietro Costa,Daniela Leonardi,Maria Martucci,Lidia Moschini,Severo Pagliardini,Giuseppe Parlato,Alberto Pignero,Aldo Pinchera,Danielle Sala,Lidia Sava,Vera Stoppioni,Francesco Tancredi,Fabiola Valentini,Riccardo Vigneri,Mariella Sorcini +25 more
TL;DR: The results suggested a multifactorial origin of CH in which genetic and environmental factors play a role in the development of the disease.
Journal Article
Longitudinal assessment of children with congenital hypothyroidism detected by neonatal screening.
Lidia Moschini,Pietro Costa,Marinelli E,Maggioni G,Sorcini Carta M,Fazzini C,A. Diodato,G. Sabini,Grandolfo Me,S. Carta +9 more
TL;DR: Clinical and laboratory data from 42 children with primary congenital hypothyroidism diagnosed by neonatal screening over a six-year period are reported, showing an impairment of posture, coordination and subtle deficits in motor and perceptual abilities in a small percentage of children.
Journal ArticleDOI
Neonatal Screening for Congenital Hypothyroidism: What Can We Learn From Discordant Twins?
Emanuela Medda,Maria Cristina Vigone,Alessandra Cassio,Francesca Calaciura,Pietro Costa,Giovanna Weber,Tiziana de Filippis,Giulia Gelmini,Marianna Di Frenna,Silvana Caiulo,Rita Ortolano,Daniela Rotondi,Monica Bartolucci,Rossella Gelsomino,Simona De Angelis,Marco Gabbianelli,Luca Persani,Olivieri A +17 more
TL;DR: This study showed that the introduction of re-screening permits the diagnosis of CH in a greater number of twins and showed the importance of long-term follow-up in both twins in the pair, and the role of non-genetic factors in the etiology of permanent CH.
RAPID COMMUNICATION Missense Mutation in the Transcription Factor NKX2-5: A Novel Molecular Event in the Pathogenesis of Thyroid Dysgenesis
Monica Dentice,Viviana Cordeddu,Annamaria Rosica,Alfonso Massimiliano Ferrara,Libero Santarpia,Domenico Salvatore,Luca Chiovato,Anna Perri,Lidia Moschini,Cristina Fazzini,Antonella Olivieri,Pietro Costa,Vera Stoppioni,Mariangiola Baserga,Mario De Felice,Mariella Sorcini,Gianfranco Fenzi,Roberto Di Lauro,Marco Tartaglia,Paolo Emidio Macchia,Stazione Zoologica,A. Dohrn +21 more
TL;DR: It is indicated that Nkx2-5(-/-) embryos exhibit thyroid bud hypoplasia, providing evidence that NKX 2-5 plays a role in thyroid organogenesis and thatNKX2- 5 mutations contribute to TD, suggesting a previously unknown role of NKX1-5 in the pathogenesis of TD.