P
Ping Xie
Researcher at Protein Sciences
Publications - 5
Citations - 367
Ping Xie is an academic researcher from Protein Sciences. The author has contributed to research in topics: Ubiquitin ligase & DNA ligase. The author has an hindex of 5, co-authored 5 publications receiving 281 citations. Previous affiliations of Ping Xie include Capital Medical University & Dalian Medical University.
Papers
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Journal ArticleDOI
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis
Ping Xie,Minghua Zhang,Shan He,Kefeng Lu,Yuhan Chen,Guichun Xing,Yiming Lu,Ping Liu,Yang Li,Shaoxia Wang,Nan Chai,Jia-Wei Wu,Haiteng Deng,Hong-Rui Wang,Yu Cao,Fei Zhao,Yu Cui,Jian Wang,Fuchu He,Lingqiang Zhang +19 more
TL;DR: Evidence that neddylation is important in HECT ubiquitin ligase activation is provided and new light is shed on the tumour-promoting role of Smurf1 is shed.
Journal ArticleDOI
An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network.
Yang Li,Ping Xie,Ping Xie,Liang Lu,Jian Wang,Lihong Diao,Lihong Diao,Zhongyang Liu,Feifei Guo,Yangzhige He,Yuan Liu,Qin Huang,Han Liang,Dong Li,Fuchu He +14 more
TL;DR: The authors take an in silico naïve Bayesian classifier approach to integrate multiple lines of evidence for E3-substrate prediction, enabling prediction of the proteome-wide human E3 ligase interaction network.
Journal ArticleDOI
The RBBP6/ZBTB38/MCM10 Axis Regulates DNA Replication and Common Fragile Site Stability
Benoit Miotto,Moredreck Chibi,Moredreck Chibi,Ping Xie,Stéphane Koundrioukoff,Hanlie Moolman-Smook,David J.R. Pugh,Michelle Debatisse,Fuchu He,Lingqiang Zhang,Pierre-Antoine Defossez +10 more
TL;DR: A pathway that is required for human genome replication and stability is reported, which has three components: an E3 ubiquitin ligase, a transcriptional repressor, and a replication protein.
Journal ArticleDOI
Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells
Benoit Miotto,Benoit Miotto,Claire Marchal,Claire Marchal,Guillaume Adelmant,Nadège Guinot,Ping Xie,Jarrod A. Marto,Lingqiang Zhang,Pierre-Antoine Defossez +9 more
TL;DR: It is found that USP9X is itself stabilized by oxidative stress, and is required together with ZBTB38 to limit the basal generation of ROS, as well as the toxicity of an acute oxidative stress.
Journal ArticleDOI
The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function.
TL;DR: Nedd8 binding site in Smurf is shown to be necessary for its ubiquitin ligase activity towards the substrate and also the self-ubiquitylation, and shown to play important roles in the regulation of cell migration and the BMP and TGFβ signaling pathways.