J
Jia-Wei Wu
Researcher at Tsinghua University
Publications - 139
Citations - 8381
Jia-Wei Wu is an academic researcher from Tsinghua University. The author has contributed to research in topics: Computer science & Medicine. The author has an hindex of 41, co-authored 88 publications receiving 7520 citations. Previous affiliations of Jia-Wei Wu include Soochow University (Suzhou) & Central China Normal University.
Papers
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Journal ArticleDOI
Structural basis of IAP recognition by Smac/DIABLO
TL;DR: The high-resolution crystal structure of Smac/DIABLO complexed with the third BIR domain (BIR3) of XIAP is reported, revealing how Smac may relieve IAP inhibition of caspase-9 activity and identifies potential targets for drug screening.
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Structural and biochemical basis of apoptotic activation by Smac/DIABLO.
TL;DR: It is shown that Smac/DIABLO promotes not only the proteolytic activation of procaspase-3 but also the enzymatic activity of mature caspases, both of which depend upon its ability to interact physically with IAPs.
Journal ArticleDOI
Crystal Structure of a UBP-Family Deubiquitinating Enzyme in Isolation and in Complex with Ubiquitin Aldehyde
Min Hu,Pingwei Li,Muyang Li,Wenyu Li,Tingting Yao,Jia-Wei Wu,Wei Gu,Robert E. Cohen,Yigong Shi +8 more
TL;DR: In this paper, the crystal structures of the 40 kDa catalytic core domain of HAUSP in isolation and in complex with ubiquitin aldehyde were reported, showing that the UBP deubiquitinating enzymes exhibit a conserved three-domain architecture, comprising Fingers, Palm and Thumb.
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The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism.
Chen-Song Zhang,Bin Jiang,Mengqi Li,Mingjiang Zhu,Yongying Peng,Yalin Zhang,Yu-Qing Wu,Terytty Yang Li,Yu Liang,Zailian Lu,Guili Lian,Qing Liu,Huiling Guo,Zhenyu Yin,Zhiyun Ye,Jiahuai Han,Jia-Wei Wu,Huiyong Yin,Shu-Yong Lin,Sheng-Cai Lin +19 more
TL;DR: This study found that the late endosomal/lysosomal protein complex v-ATPase-Ragulator, essential for activation of mTORC1, is also required for AMPK activation and uncovered that AMPK is a residential protein of late endo-lysosome.
Journal ArticleDOI
Crystal Structure of a Phosphorylated Smad2: Recognition of Phosphoserine by the MH2 Domain and Insights on Smad Function in TGF-β Signaling
Jia-Wei Wu,Min Hu,Jijie Chai,Joan Seoane,Morgan Huse,Carey Li,Daniel J. Rigotti,Saw Kyin,Tom W. Muir,Robert Fairman,Joan Massagué,Yigong Shi +11 more
TL;DR: A bifunctional role for the MH2 domain as a pSer-X-pSer binding module in receptor Ser/Thr kinase signaling pathways is defined.