P
Piotr Bregestovski
Researcher at French Institute of Health and Medical Research
Publications - 52
Citations - 7030
Piotr Bregestovski is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Glycine receptor & NMDA receptor. The author has an hindex of 32, co-authored 50 publications receiving 6818 citations. Previous affiliations of Piotr Bregestovski include University College London & Pasteur Institute.
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Genetically encoded chloride indicator with improved sensitivity.
TL;DR: A new CFP-YFP-based construct (Cl-sensor) with relatively high sensitivity to Cl (K(app) approximately 30 mM) due to triple YFP mutant and good pH sensitivity with pK(alpha) ranging from 7.1 to 8.0 pH units at different Cl concentrations is proposed.
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Elevation of intracellular calcium reduces voltage-dependent potassium conductance in human T cells
TL;DR: The results suggest that the level of intracellular calcium regulates the effective number of K+ channels capable of being activated, and that the elevation of [Ca]i decreases the potassium conductance.
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Calcium conductance of acetylcholine-induced endplate channels.
TL;DR: The elementary characteristics of the Ca2+ current are investigated by bathing muscles in CaCl2 solutions containing no Na+ ions, so that Ca2- is the only ion available to carry any appreciable inward current.
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Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival
Christophe Pellegrino,Christophe Pellegrino,Olena Gubkina,Olena Gubkina,Michael K. E. Schaefer,Michael K. E. Schaefer,Hélène Becq,Hélène Becq,Anastasia Ludwig,Anastasia Ludwig,Marat Mukhtarov,Marat Mukhtarov,Ilona Chudotvorova,Ilona Chudotvorova,Severine Corby,Severine Corby,Yuriy Salyha,Sergey Salozhin,Sergey Salozhin,Piotr Bregestovski,Piotr Bregestovski,Igor Medina,Igor Medina +22 more
TL;DR: It is shown that experimental silencing of endogenous KCC2 using an RNA interference approach or a dominant negative mutant reduces neuronal resistance to toxic insults and opens new avenues for the development of neuroprotective therapy.
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Neuronal activity in vitro and the in vivo reality: the role of energy homeostasis
TL;DR: This paper discusses the relationships between availability of energy substrates and neuronal excitability, and suggests that for in vitro studies, it is crucial to optimize the composition of the energy pool in the extracellular milieu.