Pongsiri Jaikumpun

TL;DR: H CO3− impedes the planktonic growth of different bacteria and impedes biofilm formation by P. aeruginosa that is associated with increased intracellular cAMP production, suggesting that aerosol inhalation therapy with HCO3− solutions may help improve respiratory hygiene in patients with cystic fibrosis and possibly other chronically infected lung diseases.

TL;DR: Observations indicate that sodium bicarbonate is beneficial to deltaF508-CFTR expressing CFBE cells, and may have a direct therapeutic effect on the bronchial epithelium.

TL;DR: The data show that HCO3− exerts direct antibacterial and antibiofilm effects on prevalent CF bacteria in artificial sputum medium (ASM), whose composition resembles CF mucus.

TL;DR: Bicarbonate is proposed as a simple management option for COVID-19 patients because it potentiates neutrophil extracellular trap formation and regulates macrophage polarization modulating inflammatory responses, and enhances the activity of antimicrobial peptides.

TL;DR: In this article, the effects of hypertonic saline (NaCl) and NaHCO3 on CF sputum viscoelasticity in vitro were evaluated with a rheometer at constant frequency and strain.