Z
Zoltán Rakonczay
Researcher at University of Szeged
Publications - 170
Citations - 5106
Zoltán Rakonczay is an academic researcher from University of Szeged. The author has contributed to research in topics: Pancreatitis & Acute pancreatitis. The author has an hindex of 38, co-authored 164 publications receiving 4344 citations. Previous affiliations of Zoltán Rakonczay include University of Newcastle & Hungarian Academy of Sciences.
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Journal ArticleDOI
Variants in CPA1 are strongly associated with early onset chronic pancreatitis
Heiko Witt,Sebastian Beer,Jonas Rosendahl,Jian-Min Chen,Jian-Min Chen,Giriraj R. Chandak,Atsushi Masamune,Melinda Bence,Richárd Szmola,Richárd Szmola,Grzegorz Oracz,Milan Macek,Eesh Bhatia,Sandra Steigenberger,Denise Lasher,Florence Bühler,Catherine Delaporte,Johanna Tebbing,Maren Ludwig,Claudia Pilsak,Karolin Saum,Peter Bugert,Emmanuelle Masson,Emmanuelle Masson,Sumit Paliwal,Seema Bhaskar,Agnieszka Sobczynska-Tomaszewska,Daniel Bak,Ivan Balascak,Gourdas Choudhuri,D. Nageshwar Reddy,G Venkat Rao,Varghese Thomas,Kiyoshi Kume,Eriko Nakano,Yoichi Kakuta,Tooru Shimosegawa,Lukasz Durko,András Szabó,Andrea Schnúr,Andrea Schnúr,Péter Hegyi,Zoltán Rakonczay,Roland H. Pfützer,Alexander Schneider,David A. Groneberg,Markus Braun,Hartmut Schmidt,Ulrike Witt,Helmut Friess,Hana Algül,Olfert Landt,Markus Schuelke,Renate Krüger,Bertram Wiedenmann,Frank Schmidt,Klaus Peter Zimmer,Peter Kovacs,Michael Stumvoll,Matthias Blüher,Thomas Müller,Andreas R. Janecke,Niels Teich,Robert Grützmann,Hans Ulrich Schulz,Joachim Mössner,Volker Keim,Matthias Löhr,Claude Férec,Claude Férec,Miklós Sahin-Tóth +70 more
TL;DR: The mechanism by which CPA1 variants confer increased pancreatitis risk may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity, as is seen with other genetic risk factors for this disease.
Journal ArticleDOI
The role of NF-κB activation in the pathogenesis of acute pancreatitis
TL;DR: A recent review as discussed by the authors discusses recent advances in the investigation of pancreatic and extrapancreatic (lungs, liver, monocytes and macrophages, and endothelial cells) NF-kappaB activation as it relates to acute pancreatitis.
Journal ArticleDOI
Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models
György Biczó,Eszter T. Vegh,Natalia Shalbueva,Olga A. Mareninova,Jason M. Elperin,Ethan Lotshaw,Sophie Gretler,Aurelia Lugea,Sudarshan R. Malla,David W. Dawson,Piotr Ruchala,Julian P. Whitelegge,Samuel W. French,Li Wen,Sohail Z. Husain,Fred S. Gorelick,Péter Hegyi,Péter Hegyi,Zoltán Rakonczay,Ilya Gukovsky,Anna S. Gukovskaya +20 more
TL;DR: In different animal models, a central role is found for mitochondrial dysfunction, and for impaired autophagy as its principal downstream effector, in development of AP, a model of severe AP the pathogenesis of which has remained unknown.
Journal ArticleDOI
Prospective, Multicentre, Nationwide Clinical Data from 600 Cases of Acute Pancreatitis
Andrea Párniczky,Balázs Kui,Andrea Szentesi,Andrea Szentesi,Anita Balázs,Ákos Szűcs,Dóra Mosztbacher,József Czimmer,Patrícia Sarlós,Judit Bajor,Szilárd Gódi,Áron Vincze,Anita Illés,Imre Szabó,Gabriella Pár,Tamás Takács,László Czakó,Zoltán Szepes,Zoltán Rakonczay,Ferenc Izbéki,Judit Gervain,Adrienn Halász,János Novák,Stefan Crai,István Hritz,Csaba Góg,János Sümegi,Petra A. Golovics,Márta Varga,Barnabás Bod,József Hamvas,Mónika Varga-Müller,Zsuzsanna Papp,Miklós Sahin-Tóth,Péter Hegyi,Péter Hegyi,Péter Hegyi +36 more
TL;DR: Analysis of a large, nationwide, prospective cohort of AP cases allowed for the identification of important determinants of severity and mortality, and evidence-based guidelines should be observed rigorously to improve outcomes in AP.
Journal ArticleDOI
Alcohol Disrupts Levels and Function of the Cystic Fibrosis Transmembrane Conductance Regulator to Promote Development of Pancreatitis
József Maléth,Anita Balázs,Petra Pallagi,Zsolt Balla,Balázs Kui,Máté Katona,Linda Judák,István Németh,Lajos Kemény,Zoltán Rakonczay,Viktória Venglovecz,Imre Földesi,Zoltán Pető,Áron Somorácz,Katalin Borka,Doranda Perdomo,Gergely L. Lukacs,Michael A. Gray,Stefania Monterisi,Manuela Zaccolo,Matthias Sendler,Julia Mayerle,Jens-Peter Kühn,Markus M. Lerch,Miklós Sahin-Tóth,Péter Hegyi +25 more
TL;DR: Based on studies of human, mouse, and guinea pig pancreata, alcohol disrupts expression and localization of the CFTR, which appears to contribute to development of pancreatitis.