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Ponnusamy Saravanan

Researcher at University of Warwick

Publications -  114
Citations -  3751

Ponnusamy Saravanan is an academic researcher from University of Warwick. The author has contributed to research in topics: Gestational diabetes & Pregnancy. The author has an hindex of 28, co-authored 93 publications receiving 2770 citations. Previous affiliations of Ponnusamy Saravanan include University Hospitals Coventry and Warwickshire NHS Trust & University Hospital Coventry.

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Psychological well-being in patients on 'adequate' doses of l-thyroxine: results of a large, controlled community-based questionnaire study.

TL;DR: Over 1% of the UK population is receiving thyroid hormone replacement with l‐thyroxine (T4) but many patients complain of persistent lethargy and related symptoms on T4 even with normal TSH levels, so a large, community‐based study is attempted to address this issue.
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Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients.

TL;DR: It is suggested that commonly inherited variation in the DIO2 gene is associated both with impaired baseline psychological well-being on T( 4) and enhanced response to combination T(4)/T(3) therapy, but did not affect serum thyroid hormone levels.
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High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects.

TL;DR: The data suggest that, in a compromised metabolic state such as type 2 diabetes, a continual snacking routine will cumulatively promote their condition more rapidly than in other individuals because of the greater exposure to endotoxin.