Porntula Panorchan

TL;DR: Both the mechanical properties of the cytOSkeleton and cytoskeleton-based processes, including cell motility, coupled MTOC and nucleus dynamics, and cell polarization, depend critically on the integrity of the nuclear lamina, which suggest the existence of a functional mechanical connection between the nucleus and the cytos skeleton.

TL;DR: This work develops a method that probes the biochemical and biophysical properties of the binding interactions between cadherins expressed on the surface of living cells, at the single-molecule level and suggests that N-cadherin and E-cADherin molecules form homophilic bonds between juxtaposed cells that have significantly different kinetic and micromechanical properties.

TL;DR: The results suggest that when an adherent cell is subjected to shear stresses, its first order of action is to prevent detachment from its substratum by greatly stiffening its cytoplasm through enhanced actin assembly and Rho-kinase mediated contractility.

TL;DR: It is found that VEGF treatment, which enhances endothelial migration, increases the compliance and reduces the elasticity of the cytoplasm of HUVECs in a matrix, is abrogated by specific Rho-kinase (ROCK) inhibition, suggesting that ROCK plays an essential role in the regulation of the intracellular mechanical response to VEGFs.

TL;DR: Quantitative rheological methods demonstrate that human lamin B1 filaments form stiff networks that can resist much greater deformations than those caused by microtubules impinging on the NE.