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Pradeep Kumar

Bio: Pradeep Kumar is an academic researcher from University of Delhi. The author has contributed to research in topics: Medicine & Computer science. The author has an hindex of 61, co-authored 1390 publications receiving 19257 citations. Previous affiliations of Pradeep Kumar include Guru Gobind Singh Indraprastha University & Indian Institute of Technology Roorkee.


Papers
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Journal ArticleDOI
Shamir R. Mehta1, Salim Yusuf1, Rafael Diaz, Jun Zhu2  +478 moreInstitutions (5)
26 Jan 2005-JAMA
TL;DR: In this large, international randomized trial, high-dose GIK infusion had a neutral effect on mortality, cardiac arrest, and cardiogenic shock in patients with acute STEMI.
Abstract: Context Glucose-insulin-potassium (GIK) infusion is a widely applicable, low-cost therapy that has been postulated to improve mortality in patients with acute ST-segment elevation myocardial infarction (STEMI). Given the potential global importance of GIK infusion, a large, adequately powered randomized trial is required to determine the effect of GIK on mortality in patients with STEMI. Objective To determine the effect of high-dose GIK infusion on mortality in patients with STEMI. Design, setting, and participants Randomized controlled trial conducted in 470 centers worldwide among 20,201 patients with STEMI who presented within 12 hours of symptom onset. The mean age of patients was 58.6 years, and evidence-based therapies were commonly used. Intervention Patients were randomly assigned to receive GIK intravenous infusion for 24 hours plus usual care (n = 10,091) or to receive usual care alone (controls; n = 10,110). Main outcome measures Mortality, cardiac arrest, cardiogenic shock, and reinfarction at 30 days after randomization. Results At 30 days, 976 control patients (9.7%) and 1004 GIK infusion patients (10.0%) died (hazard ratio [HR], 1.03; 95% confidence interval [CI], 0.95-1.13; P = .45). There were no significant differences in the rates of cardiac arrest (1.5% [151/10 107] in control and 1.4% [139/10,088] in GIK infusion; HR, 0.93; 95% CI, 0.74-1.17; P = .51), cardiogenic shock (6.3% [640/10 107] vs 6.6% [667/10 088]; HR, 1.05; 95% CI, 0.94-1.17; P = .38), or reinfarction (2.4% [246/10,107] vs 2.3% [236/10,088]; HR, 0.98; 95% CI, 0.82-1.17; P = .81). The rates of heart failure at 7 days after randomization were also similar between the groups (16.9% [1711/10,107] vs 17.1% [1721/10,088]; HR, 1.01; 95% CI, 0.95-1.08; P = .72). The lack of benefit of GIK infusion on mortality was consistent in prespecified subgroups, including in those with and without diabetes, in those presenting with and without heart failure, in those presenting early and later after symptom onset, and in those receiving and not receiving reperfusion therapy (thrombolysis or primary percutaneous coronary intervention). Conclusion In this large, international randomized trial, high-dose GIK infusion had a neutral effect on mortality, cardiac arrest, and cardiogenic shock in patients with acute STEMI.

624 citations

Book
01 Jan 2005
TL;DR: In this paper, the authors present a synthesis and integration of the findings of the four MA Working Groups (Condition and Trends, Scenarios, Responses, and Sub-global Assessments).
Abstract: This report presents a synthesis and integration of the findings of the four MA Working Groups (Condition and Trends, Scenarios, Responses, and Sub-global Assessments). It does not, however, provide a comprehensive summary of each Working Group report, and readers are encouraged to also review the findings of these separately. This synthesis is organized around the core questions originally posed to the assessment: How have ecosystems and their services changed? What has caused these changes? How have these changes affected human well-being? How might ecosystems change in the future and what are the implications for human well-being? And what options exist to enhance the conservation of ecosystems and their contribution to human well-being?

500 citations

Journal ArticleDOI
TL;DR: In this paper, a study has been made to optimize the process parameters of powder mixed electrical discharge machining (PMEDM), and the results identify the most important parameters to maximize material removal rate and minimize surface roughness.

402 citations

Journal ArticleDOI
TL;DR: In this article, a two-phase research approach has been proposed and used in this study, in the first phase, six categories of risks and twenty-five specific risks, associated with the GSC, were identified.
Abstract: Due to increase in customer environmental awareness, competitiveness and strict governmental policies, the approach of incorporating green supply chain management (GSCM), to conserve resources and sustainable production, is gradually becoming more imperative for organizations. However, the successful accomplishment of green supply chain (GSC) production and business activities is relatively difficult due to involvement of different risks. These risks and their respective sources have a tendency to disturb the GSC functioning, and thereby, decline in the ecological-economic performance. Therefore, identification of risks and their subsequent analysis in the GSC are very important to know and understand. The present research analyzes the risks relevant to adoption and effective implementation of GSC practices at industrial viewpoint. A two-phase research approach has been proposed and used in this study. In the first phase, six categories of risks and twenty-five specific risks, associated with the GSC, were identified. The basis of identification of the risks was literature and inputs received from experts from industries. Experts’ opinion has been collected from the officials and managers of four Indian poly product-manufacturing companies. In the second phase, the fuzzy analytic hierarchy process (fuzzy AHP), a qualitative and quantitative analysis was used to analyze the identified risks for determining of their priority of concern. The used fuzzy AHP approach is also useful in dealing with the human subjectivity and ambiguity involved in the process of risk analysis. In this research, an effort has been made to know the most important risk in GSC context, and the findings would be useful for industries in managing and reducing the consequences of the risks in GSC. The analysis of the results indicates that operational category risks are the most important risks in GSC. Sensitivity analysis is also conducted to examine the priority ranking stability.

359 citations


Cited by
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Journal Article
TL;DR: This book by a teacher of statistics (as well as a consultant for "experimenters") is a comprehensive study of the philosophical background for the statistical design of experiment.
Abstract: THE DESIGN AND ANALYSIS OF EXPERIMENTS. By Oscar Kempthorne. New York, John Wiley and Sons, Inc., 1952. 631 pp. $8.50. This book by a teacher of statistics (as well as a consultant for \"experimenters\") is a comprehensive study of the philosophical background for the statistical design of experiment. It is necessary to have some facility with algebraic notation and manipulation to be able to use the volume intelligently. The problems are presented from the theoretical point of view, without such practical examples as would be helpful for those not acquainted with mathematics. The mathematical justification for the techniques is given. As a somewhat advanced treatment of the design and analysis of experiments, this volume will be interesting and helpful for many who approach statistics theoretically as well as practically. With emphasis on the \"why,\" and with description given broadly, the author relates the subject matter to the general theory of statistics and to the general problem of experimental inference. MARGARET J. ROBERTSON

13,333 citations

01 Jan 2002

9,314 citations

Posted Content
TL;DR: Deming's theory of management based on the 14 Points for Management is described in Out of the Crisis, originally published in 1982 as mentioned in this paper, where he explains the principles of management transformation and how to apply them.
Abstract: According to W. Edwards Deming, American companies require nothing less than a transformation of management style and of governmental relations with industry. In Out of the Crisis, originally published in 1982, Deming offers a theory of management based on his famous 14 Points for Management. Management's failure to plan for the future, he claims, brings about loss of market, which brings about loss of jobs. Management must be judged not only by the quarterly dividend, but by innovative plans to stay in business, protect investment, ensure future dividends, and provide more jobs through improved product and service. In simple, direct language, he explains the principles of management transformation and how to apply them.

9,241 citations