Showing papers in "Asian Journal of Pharmaceutical Sciences in 2014"

TL;DR: A review of solid particle technologies available for improving solubility, dissolution, and bioavailability of drugs with poor aqueous solubilities is presented in this article, where the authors highlight the solid particle technology available to improve the bioavailability.

TL;DR: This review introduces the basic concepts of polymorphism, addresses a fundamental question of “Why do polymorphs form?”, and provides practical guidelines of how to prepare polymorphs and how to evaluate the relative thermodynamic stability between polymorphs.

TL;DR: The cross-linked mixtures of high amylose and pectin showed a suitable excipient for slowing the drug release rates and was influenced by both polymer ratio and cross-linking process.

TL;DR: This review introduces recent advances in nanocarrier-based vaccine delivery systems, with a focus on the types of carriers, including liposomes, emulsions, polymer-based particles, and carbon-based nanomaterials.

TL;DR: A review of new techniques being used for the preparation of liposomes is presented in this paper, where the advantages and drawbacks of the latest techniques are reviewed and a total of 28 publications are examined.

TL;DR: In this article, the electrochemical behavior of paclitaxel drug was studied at a glassy carbon electrode in phosphate buffer solutions using cyclic and differential-pulse voltammetric techniques.

TL;DR: An overview of the investigations in this field was presented, and further implications on selection or design of suitable permeation enhancers for transdermal drug delivery were also discussed.

TL;DR: In this article, the authors investigated the spray-dried lactose as carrier for dry powder inhalation (DPI), and the particle size, shape and crystal form were characterized by laser diffraction, scanning electron microscopy (SEM), X-ray diffraction (XRD), and differential scanning calorimetry (DSC).

TL;DR: The amino acid transporter SLC6A14 holds great potential not only as a direct drug target for cancer therapy but also for tumor cell-selective delivery of anticancer drugs.

TL;DR: In this article, an immediate release solid dispersion (SD) formulation of antiulcer drug lafutidine (LAFT) was developed using hot melt extrusion (HME) technique.

TL;DR: In this paper, a redox-responsive PEG-sheddable copolymer of disulfide-linked polyethylene glycol 5000-lysine-di-tocopherol succinate (P 5k SSLV) was designed and synthesized.

TL;DR: The biological functions of SA and PSA are summarized and the technologies of SA/PSA modified small molecule drugs, proteins and carriers in drug delivery systems are presented.

TL;DR: Advances of prodrug approaches for enhancing oral absorption of nucleoside analogues are presented.

TL;DR: In this article, the effect of tea tree oil (TTO), cumin oil (CO), rose oil (RO), and aloe vera oil (AVO) on the skin permeation of losartan potassium (LP) was investigated.

TL;DR: In this article, the authors used failure mode and effect analysis (FMEA) methodology to assess the most important variables affecting enteric-coated pellets characteristics, and a Box-Behnken design was subsequently used for investigating the main, interactive, and quadratic effects of these variables on the response.

TL;DR: In this paper, a combination of inorganic mesoporous silica material, frequently used as drug carriers, and a natural organic polymer alginate (ALG) was used to establish a sustained drug delivery system for the poorly water-soluble drug Indomethacin (IND).

TL;DR: Clinical practices proved that fixed-dose combinations had many benefits comparing with single drug and separate agents in terms of effects, convenience, compliance, and costs to a certain extent and from the patients' perspective, the fixed- dose combination therapy will be increasingly utilized in blood pressure control in the future.

TL;DR: The optimized compound patch containing diclofenac-triethylamine and TEF-TEtA displayed significant anti-inflammatory and analgesic effect, which indicated the potential of the compound patch.

TL;DR: Since the M-cell in the intestinal epithelium played an important role in particle transportation as well as intimately associated with the underlying immune cells, the OVA-Lipid NPs effectively induced mucosal and humoral immune responses.

TL;DR: In this paper, various phases of GMO/solvent system containing sodium fluorescein were prepared to compare permeability using confocal laser scanning microscopy (CLSM), and the results showed that the mixture had the weakest permeability compared to the other two phases.

TL;DR: This investigation has solved the problems of oral solid dosage forms of NMD, and it has the good industry prospect.

TL;DR: In this article, the authors used a hydrophilic phosphonate-terminated magnetic mesoporous nanoparticles (pMMSNs) to enhance the negative surface charge of MMSNs.

TL;DR: In this review, unique spray nozzles for the preparation of nanocomposite particles which mean microparticles containing drug nanoparticles are described and useful in improving drug absorption and delivery efficacy against alveolar macrophages.

TL;DR: In this article, a simple and rapid method was developed to improve the in-vitro dissolution of repaglinide, an oral antidiabetic drug, which was based on addition of meglumine in 50% (v/v) ethanol to dissolve repagside, and the drug dissolved in megluminine/50% ethanol was used directly with a binder to prepare tablets.

TL;DR: Findings indicate that PLD- b-PEG-b-PLD polypeptide micelles are a promising approach for anti-cancer drug delivery.

TL;DR: In this paper, a simple, accurate, precise and robust HPLC method was developed for the simultaneous determination of fimasartan and amlodipine in tablet dosage form.

TL;DR: A simple HPLC method coupled with an evaporative light scattering detector (ELSD) was developed for the determination of azithromycin in raw materials and pharmaceutical formulations without any pretreatment or derivatization step as discussed by the authors.

TL;DR: Oral pharmacokinetics of the two tablets and one AZI dispersible tablet as reference were studied in six healthy beagle dogs after oral administration and indicated there was no significant difference between F-I and F-II, which means that the extended release rate did not induce different pharmacokinetic in vivo.

TL;DR: In this article, a time-released monolithic osmotic pump (TMOP) tablets containing diltiazem hydrochloride (DIL) were prepared on the basis of osmotics pumping mechanism.

TL;DR: In this article, a novel study using LC-MS coupled with multivariate data analysis and bioactivity evaluation was established for discrimination of aqueous extract and vinegar extract of Shixiao San.