Hyun-Il Kim

TL;DR: A review of solid particle technologies available for improving solubility, dissolution, and bioavailability of drugs with poor aqueous solubilities is presented in this article, where the authors highlight the solid particle technology available to improve the bioavailability.

TL;DR: This article described the synthesis and in vitro antiproliferative activities a series of 6-(4-fluorophenyl)-5-(2-substituted pyrimidin-4-yl)imidazo[2,1-b]thiazole derivatives, which were tested for in vitro antitumor effect against a panel of 55 cell lines of nine different cancer types at the NCI.

TL;DR: Compound IIa is proposed to be a promising prodrug of olmesartan and its in vitro stability in rat plasma showed that the ester derivative IIa with n-octyl substituted dioxolone moiety was rapidly converted into olmesartsan within 30 min.

TL;DR: Olmesartan hexetil is proposed to be an efficient prodrug of olmesartsan with markedly increased oral bioavailability and C(max) and AUC(last) for olmesartans were significantly increased in case of hexetic prodrug, compared with olmesARTan medoxomil.

TL;DR: Results indicate that compounds 13 and 14 with cyclohexylcarboxyethyl and adamantyl carboxymethyl promoieties, respectively, are promising prodrugs of olmesartan with markedly increased oral bioavailability.