P
Praveen Nedumpully-Govindan
Researcher at Clemson University
Publications - 10
Citations - 399
Praveen Nedumpully-Govindan is an academic researcher from Clemson University. The author has contributed to research in topics: Docking (molecular) & Protein aggregation. The author has an hindex of 9, co-authored 10 publications receiving 337 citations. Previous affiliations of Praveen Nedumpully-Govindan include Aalto University.
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Journal ArticleDOI
Stabilizing off-pathway oligomers by polyphenol nanoassemblies for IAPP aggregation inhibition
Praveen Nedumpully-Govindan,Aleksandr Kakinen,Emily H. Pilkington,Thomas P. Davis,Thomas P. Davis,Pu Chun Ke,Feng Ding +6 more
TL;DR: This study uses discrete molecular dynamics simulations and high-throughput dynamic light scattering experiments to study the anti-aggregation effects of two polyphenols, curcumin and resveratrol, on the aggregation of islet amyloid polypeptide (IAPP or amylin).
Journal ArticleDOI
Graphene oxide inhibits hIAPP amyloid fibrillation and toxicity in insulin-producing NIT-1 cells
Praveen Nedumpully-Govindan,Esteban Nicolas Gurzov,Esteban Nicolas Gurzov,Pengyu Chen,Emily H. Pilkington,William J Stanley,William J Stanley,Sara A Litwak,Thomas P. Davis,Thomas P. Davis,Pu Chun Ke,Feng Ding +11 more
TL;DR: This multidisciplinary study suggests that GO nanosheets have the potential to be utilized as an anti-aggregation nanomedicine itself in addition to a biosensor or delivery vehicle for the mitigation of T2D progression.
Journal ArticleDOI
Inhibition of IAPP aggregation by insulin depends on the insulin oligomeric state regulated by zinc ion concentration
TL;DR: Zn deficiency due to loss-of-function ZnT8 mutations shifts insulin oligomer equilibrium toward zinc-free monomers and dimers, which bind IAPP monomers more efficiently compared to zinc-bound hexamers, reducing T2D risk.
Journal ArticleDOI
Effect of fullerenol surface chemistry on nanoparticle binding-induced protein misfolding
Slaven Radic,Praveen Nedumpully-Govindan,Praveen Nedumpully-Govindan,Ran Chen,Emppu Salonen,Jared M. Brown,Pu Chun Ke,Feng Ding +7 more
TL;DR: In this paper, the effect of hydroxylation on protein-nanoparticle interactions using a model protein, ubiquitin, was investigated using a set of complementary computational methods, including docking and molecular dynamics simulations with both explicit and implicit solvent.
Journal Article
Effect of fullerenol surface chemistry on nanoparticle binding-induced protein misfolding
Slaven Radic,Praveen Nedumpully-Govindan,Ran Chen,Emppu Salonen,Jared M. Brown,Pu Chun Ke,Feng Ding +6 more
TL;DR: Overall, the results revealed a distinct role of surface chemistry on nanoparticle-protein binding and binding-induced protein misfolding.