Prem Prakash Kushwaha

TL;DR: Screening of compounds from Curcuma longa L. (Zingiberaceae family) against Mpro protein inhibition provided lead on two natural Mpro inhibitors for further testing and development as therapeutics against human coronavirus.

TL;DR: In this paper, the authors have identified some novel lead phytochemicals present in Azadirachta indica and Aloe barbadensis which could be utilized for further in vitro and in vivo anti-SARS-CoV-2 drug discovery.

TL;DR: B. frutescens phytochemicals have the ability to downregulate the notch signaling pathway in triple-negative and luminal breast cancer cells and show better anti-cancer properties.

TL;DR: This comprehensive review provides information about the structure, function, targets, and regulators of ZBTB7A and its role as an oncogenic driver and transcriptional repressor in various human diseases.

TL;DR: Mechanistic investigations revealed that all of the three substances induce apoptotic cell death via its intrinsic pathway by causing deformation of the nuclear membrane, disruption of the mitochondrial membrane potential (MMP), and elevated reactive oxygen species (ROS) production in both cell lines.