S
Shaimaa Fayez
Researcher at University of Würzburg
Publications - 27
Citations - 305
Shaimaa Fayez is an academic researcher from University of Würzburg. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 6, co-authored 14 publications receiving 129 citations. Previous affiliations of Shaimaa Fayez include Ain Shams University.
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Journal ArticleDOI
Ancistrolikokine E3, a 5,8'-Coupled Naphthylisoquinoline Alkaloid, Eliminates the Tolerance of Cancer Cells to Nutrition Starvation by Inhibition of the Akt/mTOR/Autophagy Signaling Pathway.
Suresh Awale,Dya Fita Dibwe,Chandrasekar Balachandran,Shaimaa Fayez,Doris Feineis,Blaise Kimbadi Lombe,Blaise Kimbadi Lombe,Gerhard Bringmann +7 more
TL;DR: This study provides the first live evidence of the effect of a naphthyldihydroisoquinoline alkaloid against PANC-1 cells in nutrient-deprived medium and demonstrated that ancistrolikokine E3 is a potent early-stage inhibitor of the autophagy pathway in PANC -1 human pancreatic cancer cells.
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Induction of apoptosis in breast cancer cells by naphthylisoquinoline alkaloids.
Prem Prakash Kushwaha,Atul Kumar Singh,Kumari Sunita Prajapati,Mohd Shuaib,Shaimaa Fayez,Gerhard Bringmann,Shashank Kumar +6 more
TL;DR: Mechanistic investigations revealed that all of the three substances induce apoptotic cell death via its intrinsic pathway by causing deformation of the nuclear membrane, disruption of the mitochondrial membrane potential (MMP), and elevated reactive oxygen species (ROS) production in both cell lines.
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A Near-Complete Series of Four Atropisomeric Jozimine A2-Type Naphthylisoquinoline Dimers with Antiplasmodial and Cytotoxic Activities and Related Alkaloids from Ancistrocladus abbreviatus.
Shaimaa Fayez,Shaimaa Fayez,Jun Li,Jun Li,Doris Feineis,Laurent Aké Assi,Marcel Kaiser,Marcel Kaiser,Reto Brun,Reto Brun,Mohamed A. Anany,Harald Wajant,Gerhard Bringmann +12 more
TL;DR: Three new naphthylisoquinoline dimers, jozibrevines A-C (1a-c), were isolated from the West African shrub Ancistrocladus abbreviatus, along with the known dimer jozimine A2 (1d), which showed cytotoxicity against human colon carcinoma, fibrosarcoma, and multiple myeloma cells.
Journal ArticleDOI
Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana Ancistrocladus abbreviatus with inhibitory activities against Plasmodium falciparum and PANC-1 human pancreatic cancer cells.
Shaimaa Fayez,Doris Feineis,Laurent Aké Assi,Marcel Kaiser,Marcel Kaiser,Reto Brun,Reto Brun,Suresh Awale,Gerhard Bringmann +8 more
TL;DR: Five known compounds, previously discovered in related African and Asian Ancistrocladus species, have now for the first time been identified in A. abbreviatus and exhibited promising activities against the malaria parasite Plasmodium falciparum and PANC-1 human pancreatic cancer cells.
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Ancistrolikokines E–H and related 5,8′-coupled naphthylisoquinoline alkaloids from the Congolese liana Ancistrocladus likoko with antiausterity activities against PANC-1 human pancreatic cancer cells
TL;DR: Nine new compounds of this coupling type isolated from the twigs of this remarkable Central African liana showed moderate to good preferential cytotoxic activities towards pancreatic PANC-1 cells in nutrient-deprived medium (NDM), without causing toxicity under normal, nutrient-rich conditions.