Q
Qi Chen
Researcher at Capital Medical University
Publications - 9
Citations - 432
Qi Chen is an academic researcher from Capital Medical University. The author has contributed to research in topics: Ziprasidone & Positive and Negative Syndrome Scale. The author has an hindex of 5, co-authored 7 publications receiving 354 citations. Previous affiliations of Qi Chen include Central South University.
Papers
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Journal ArticleDOI
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2
Wei Hua Yue,Haifeng Wang,Haifeng Wang,Liangdan Sun,Fu Lei Tang,Zhonghua Liu,Hongxing Zhang,Wen Qiang Li,Yan Ling Zhang,Yang Zhang,Cui Cui Ma,Bo Du,Lifang Wang,Yun Qing Ren,Yong Feng Yang,Xiao Feng Hu,Yi Wang,Yi Wang,Wei Deng,Li Wen Tan,Yun Long Tan,Qi Chen,Guang Ming Xu,Gui Gang Yang,Xian Bo Zuo,Hao Yan,Yan Yan Ruan,Tian Lan Lu,Xue Han,Xiao Hong Ma,Yan Wang,Li Wei Cai,Chao Jin,Hongyan Zhang,Jun Yan,Wei Feng Mi,Xianyong Yin,Wen Bin Ma,Qi Liu,Lan Kang,Wei Sun,Cheng Ying Pan,Mei Shuang,Fu De Yang,Chuanyue Wang,Jianli Yang,Ke Qing Li,Xin Ma,Ling Jiang Li,Xin Yu,Qizhai Li,Xun Huang,Lu Xian Lv,Tao Li,Guoping Zhao,Wei Huang,Wei Huang,Xuejun Zhang,Dai Zhang +58 more
TL;DR: It is found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain and may lead to new insights into the pathogenesis of schizophrenia.
Journal ArticleDOI
Five novel loci associated with antipsychotic treatment response in patients with schizophrenia: a genome-wide association study.
Hao Yu,Hao Yu,Hao Yan,Lifang Wang,Jun Li,Liwen Tan,Wei Deng,Qi Chen,Guigang Yang,Fuquan Zhang,Tianlan Lu,Jianli Yang,Keqing Li,Luxian Lv,Qingrong Tan,Hongyan Zhang,Xiao Xiao,Ming Li,Ming Li,Xin Ma,Fude Yang,Lingjiang Li,Chuanyue Wang,Tao Li,Dai Zhang,Dai Zhang,Weihua Yue +26 more
TL;DR: The identification of genes related to synaptic function, neurotransmitter receptors, and schizophrenia risk that are associated with response to antipsychotics improve understanding of the mechanisms underlying treatment responses, and the identified biomarkers could eventually guide choice of antipsychotic in patients with schizophrenia.
Journal ArticleDOI
Effect of Damaging Rare Mutations in Synapse-Related Gene Sets on Response to Short-term Antipsychotic Medication in Chinese Patients With Schizophrenia: A Randomized Clinical Trial.
Qiang Wang,Hei Man Wu,Weihua Yue,Hao Yan,Yamin Zhang,Liwen Tan,Wei Deng,Qi Chen,Guigang Yang,Tianlan Lu,Lifang Wang,Fuquan Zhang,Jianli Yang,Keqing Li,Luxian Lv,Qingrong Tan,Hongyan Zhang,Xin Ma,Fude Yang,Lingjiang Li,Chuanyue Wang,Xiaohong Ma,Liansheng Zhao,Hongyan Ren,Hao Yu,Yingcheng Wang,Xun Hu,Dai Zhang,Pak C. Sham,Tao Li +29 more
TL;DR: Genetic variation in glutamatergic or NMDA neurotransmission is implicated in short-term antipsychotic medication efficacy; WES may have utility in the study of rare genetic variation in pharmacogenetics.
Journal ArticleDOI
Metabolic Effects of 7 Antipsychotics on Patients With Schizophrenia: A Short-Term, Randomized, Open-Label, Multicenter, Pharmacologic Trial.
Yamin Zhang,Qiang Wang,Gavin P. Reynolds,Weihua Yue,Wei Deng,Hao Yan,Liwen Tan,Chuanyue Wang,Guigang Yang,Tianlan Lu,Lifang Wang,Fuquan Zhang,Jianli Yang,Keqing Li,Luxian Lv,Qingrong Tan,Yinfei Li,Hua Yu,Hongyan Zhang,Xin Ma,Fude Yang,Lingjiang Li,Qi Chen,Wei Wei,Liansheng Zhao,Huiyao Wang,Xiaojing Li,Wanjun Guo,Xun Hu,Yang Tian,Hongyan Ren,Xiaohong Ma,Jeremy W. Coid,Dai Zhang,Tao Li +34 more
TL;DR: Metabolic traits should be monitored frequently in early stages of antipsychotic treatment due to rapid and substantial changes, and Clinicians should not assume low risk for patients with normal metabolic parameters at baseline.
Journal ArticleDOI
Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance
Yamin Zhang,Hongyan Ren,Qiang Wang,Wei Deng,Weihua Yue,Hao Yan,Liwen Tan,Qi Chen,Guigang Yang,Tianlan Lu,Lifang Wang,Fuquan Zhang,Jianli Yang,Keqing Li,Luxian Lv,Qingrong Tan,Hongyan Zhang,Xin Ma,Fude Yang,Lingjiang Li,Chuanyue Wang,Dai Zhang,Liansheng Zhao,Huiyao Wang,Xiaojing Li,Wanjun Guo,Xun Hu,Yang Tian,Xiaohong Ma,Tao Li +29 more
TL;DR: The association between rs489693 and the metabolic measures is ubiquitous but moderate, and two SNPs confer risk of AIMD to patients treated with different antipsychotics in a similar way.