Q
Qian Chen
Researcher at Third Military Medical University
Publications - 12
Citations - 309
Qian Chen is an academic researcher from Third Military Medical University. The author has contributed to research in topics: Glioma & Cancer. The author has an hindex of 8, co-authored 12 publications receiving 206 citations.
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Journal ArticleDOI
Autophagy-induced KDR/VEGFR-2 activation promotes the formation of vasculogenic mimicry by glioma stem cells.
Hai-Bo Wu,Shuai Yang,Hai-Yan Weng,Qian Chen,Xi-Long Zhao,Wen-Juan Fu,Qin Niu,Yi-Fang Ping,Ji Ming Wang,Xia Zhang,Xiao-Hong Yao,Xiu-Wu Bian +11 more
TL;DR: A crucial role of autophagy is demonstrated in the formation of VM by GSCs, which may serve as a therapeutic target in drug-resistant glioma.
Journal ArticleDOI
Stanniocalcin-1 augments stem-like traits of glioblastoma cells through binding and activating NOTCH1
Yong Li,Zhi-Cheng He,Xiao-Ning Zhang,Qing Liu,Cong Chen,Zheng Zhu,Qian Chen,Yu Shi,Xiao-Hong Yao,You-Hong Cui,Xia Zhang,Yan Wang,Hsiang-Fu Kung,Hsiang-Fu Kung,Yi-Fang Ping,Yi-Fang Ping,Xiu-Wu Bian,Xiu-Wu Bian +17 more
TL;DR: It is shown that Stanniocalcin-1 (STC1), a secretory glycoprotein, functions as a novel stimulator for stem-like traits of GBM cells and acts as a crucial regulator of stemness in GBM.
Journal ArticleDOI
Mitochondrial pyruvate carrier 1 functions as a tumor suppressor and predicts the prognosis of human renal cell carcinoma
Xiao-Peng Tang,Qian Chen,Yi Li,Yan Wang,Hongbo Zou,Wen-Juan Fu,Qin Niu,Qian-Guang Pan,Pei Jiang,Xiaosong Xu,Keqin Zhang,Hong Liu,Xiu-Wu Bian,Xiong-fei Wu +13 more
TL;DR: Investigation of expression of MPC1 and MPC2 in specimens from RCC patients and results identify anti-tumor function ofMPC1 in RCC and reveal MPC 1 as a novel prognostic biomarker to predict better patient survival.
Journal ArticleDOI
PTP1B promotes aggressiveness of breast cancer cells by regulating PTEN but not EMT.
Xue Liu,Qian Chen,Xu-gang Hu,Xian-Chao Zhang,Ti-Wei Fu,Qing Liu,Yan Liang,Xi-Long Zhao,Xia Zhang,Yi-Fang Ping,Xiu-Wu Bian +10 more
TL;DR: PTP1B promoted breast cancer metastasis by regulating phosphatase and tensin homolog (PTEN) but not epithelial-mesenchymal transition (EMT), and was positively associated with lymph node metastasis and estrogen receptor (ER) status.
Journal Article
SOX5 interacts with YAP1 to drive malignant potential of non-small cell lung cancer cells.
Hongbo Zou,Shuang Wang,Shuang Wang,Songtao Wang,Songtao Wang,Hong Wu,Hong Wu,Jing Yu,Jing Yu,Qian Chen,Wei Cui,Ye Yuan,Xianmei Wen,Jian He,Lin Chen,Ruilian Yu,Ming Zhang,Haitao Lan,Guoxiang Jin,Xia Zhang,Xiu-Wu Bian,Chuan Xu,Chuan Xu +22 more
TL;DR: It is identified that SOX5 acts as an oncogenic factor by interacting with YAP1 in NSCLC cells and may be a potential therapeutic target forNSCLC patients.