Qian Zhang

TL;DR: Findings indicate that neither auxotrophic mutations, nor vaccinia virus deficient for the thymidine kinase gene, nor anaerobic growth conditions were required for tumor specificity and intratumoral replication.

TL;DR: It is suggested that immune activation may combine with viral oncolysis to induce tumor eradication in this model, providing a novel perspective for the design of on colytic viral therapies for human cancers.

TL;DR: Evidence is provided that gene-evoked production of melanin can be used as a therapeutic and diagnostic mediator as exemplified by insertion of only one or two genes into the genome of an oncolytic vaccinia virus strain, and produced melanin is an excellent reporter for optical imaging without addition of substrate.

TL;DR: The GLV-1h68 strain showed outstanding therapeutic effects and a documented safety profile in mice, with great promise for future clinical development.

TL;DR: The construction of 3 VACV strains encoding GLAF-1, a previously undescribed engineered single-chain antibody (scAb), which exhibited significantly enhanced therapeutic efficacy in comparison to treatment of human tumor xenografts with the parental virus GLV-1h68.