W
Werner Goebel
Researcher at Ludwig Maximilian University of Munich
Publications - 368
Citations - 27245
Werner Goebel is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Listeria monocytogenes & Escherichia coli. The author has an hindex of 85, co-authored 367 publications receiving 26106 citations. Previous affiliations of Werner Goebel include University of Würzburg & Schering AG.
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Journal ArticleDOI
Listeria pathogenesis and molecular virulence determinants.
José A. Vázquez-Boland,José A. Vázquez-Boland,Michael Kuhn,Patrick Berche,Trinad Chakraborty,Gustavo Domínguez-Bernal,Werner Goebel,Bruno Gonzalez-Zorn,Jürgen Wehland,Jürgen Kreft +9 more
TL;DR: The molecular determinants of Listeria virulence and their mechanism of action are described and the current knowledge on the pathophysiology of listeriosis and the cell biology and host cell responses to Listersia infection is summarized.
Journal ArticleDOI
Comparative Genomics of Listeria Species
Philippe Glaser,Lionel Frangeul,Carmen Buchrieser,Christophe Rusniok,Alexandra Amend,Fernando Baquero,Patrick Berche,H Bloecker,P Brandt,Trinad Chakraborty,Alain Charbit,Farid Chetouani,Elisabeth Couvé,A de Daruvar,Pierre Dehoux,Eugen Domann,Gustavo Domínguez-Bernal,Eric Duchaud,Lionel Durant,Olivier Dussurget,K-D Entian,Hafida Fsihi,F García-del Portillo,P. Garrido,Laurent Gautier,Werner Goebel,Nuria Gomez-Lopez,Torsten Hain,Jörg Hauf,D Jackson,L-M Jones,U Kaerst,Jürgen Kreft,Michael Kuhn,F. Kunst,G Kurapkat,Encarnación Madueño,A Maitournam,J Mata Vicente,E Ng,Hafed Nedjari,G Nordsiek,Susana Novella,B de Pablos,José-Claudio Perez-Diaz,R Purcell,B Remmel,Matthias Rose,T Schlueter,N Simoes,A. Tierrez,José A. Vázquez-Boland,Hamut Voss,Jürgen Wehland,Pascale Cossart +54 more
TL;DR: A large number of predicted genes encoding surface and secreted proteins, transporters, and transcriptional regulators are found, consistent with the ability of both species to adapt to diverse environments.
Journal ArticleDOI
Molecular determinants of Listeria monocytogenes pathogenesis
TL;DR: The cell biology of L. monocytogenes infection has been characterized at the morphological level and is summarized as follows: Shortly thereafter, bacteria escape from host vacuoles and enter the cytoplasm, where rapid growth ensues.
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A novel bacterial virulence gene in Listeria monocytogenes required for host cell microfilament interaction with homology to the proline-rich region of vinculin.
Eugen Domann,Jürgen Wehland,Manfred Rohde,S. Pistor,M Hartl,Werner Goebel,M Leimeister-Wächter,M. Wuenscher,Trinad Chakraborty +8 more
TL;DR: Within the cytoplasm of the infected cells, the mutant strain grew as microcolonies, was unable to accumulate actin following escape from the phagocytic compartment and was incapable of infecting adjacent cells, demonstrating that the capacity to move intracellularly and spread intercellularly is a key determinant of L.monocytogenes virulence.
Journal ArticleDOI
Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins
Yong A. Yu,Yong A. Yu,Shahrokh Shabahang,Tatyana Timiryasova,Tatyana Timiryasova,Qian Zhang,Richard E. Beltz,Ivaylo Gentschev,Werner Goebel,Aladar A. Szalay,Aladar A. Szalay +10 more
TL;DR: Findings indicate that neither auxotrophic mutations, nor vaccinia virus deficient for the thymidine kinase gene, nor anaerobic growth conditions were required for tumor specificity and intratumoral replication.