T
Tatyana Timiryasova
Researcher at Loma Linda University
Publications - 33
Citations - 1324
Tatyana Timiryasova is an academic researcher from Loma Linda University. The author has contributed to research in topics: Virus & Glioma. The author has an hindex of 19, co-authored 33 publications receiving 1273 citations. Previous affiliations of Tatyana Timiryasova include Reuben H. Fleet Science Center.
Papers
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Journal ArticleDOI
Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins
Yong A. Yu,Yong A. Yu,Shahrokh Shabahang,Tatyana Timiryasova,Tatyana Timiryasova,Qian Zhang,Richard E. Beltz,Ivaylo Gentschev,Werner Goebel,Aladar A. Szalay,Aladar A. Szalay +10 more
TL;DR: Findings indicate that neither auxotrophic mutations, nor vaccinia virus deficient for the thymidine kinase gene, nor anaerobic growth conditions were required for tumor specificity and intratumoral replication.
Patent
Microorganisms for therapy
TL;DR: In this article, the microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms.
Journal ArticleDOI
Optical imaging: bacteria, viruses, and mammalian cells encoding light-emitting proteins reveal the locations of primary tumors and metastases in animals.
Yong A. Yu,Yong A. Yu,Tatyana Timiryasova,Tatyana Timiryasova,Qian Zhang,Qian Zhang,Richard E. Beltz,Aladar A. Szalay,Aladar A. Szalay,Aladar A. Szalay +9 more
TL;DR: When light-emitting protein encoded BVMC are injected systemically into rodents, tumor-specific marker gene expression is achieved and is detected in real time based on light emission, and the locations of primary tumors and previously unknown metastases in animals are revealed in vivo.
Journal ArticleDOI
Lister strain of vaccinia virus armed with endostatin–angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancer
James R. Tysome,Arnaud Briat,Ghassan Alusi,Fengyu Cao,Dongling Gao,Jinxia Yu,Pengju Wang,Shaolong Yang,Ziming Dong,Shengdian Wang,Liufu Deng,Jennelle Francis,Tatyana Timiryasova,Istvan Fodor,Nicholas R. Lemoine,Nicholas R. Lemoine,Yaohe Wang,Yaohe Wang +17 more
TL;DR: It is suggested that the novel Lister strain of vaccinia virus armed with the endostatin–angiostatin fusion gene is a potential therapeutic agent for pancreatic cancer.
Journal Article
Antitumor effect of vaccinia virus in glioma model.
Tatyana Timiryasova,Jun Li,Bing Chen,Daniel K.X. Chong,William H. R. Langridge,Daila S. Gridley,Istvan Fodor +6 more
TL;DR: Experimental results indicate that vaccinia virus itself and vaccinia-mediated delivery of therapeutic genes represent novel potential strategies for tumor therapy.