Harveen Dhillon

TL;DR: It is established that βARs are necessary for diet- induced thermogenesis and that this efferent pathway plays a critical role in the body's defense against diet-induced obesity.

TL;DR: It is shown that leptin depolarizes and increases the firing rate of steroidogenic factor-1 (SF1)-positive neurons in the VMH, and that leptin action at this site plays an important role in reducing body weight and, of note, in resisting diet-induced obesity.

TL;DR: Glutamate release from VMH neurons is an important component of the neurocircuitry that functions to prevent hypoglycemia in mice lacking VGLUT2 selectively in SF1 neurons.

TL;DR: A genome-wide Cas9-mediated screen to identify factors that are protective during RC inhibition highlights the hypoxia response, an endogenous program evolved to adapt to limited oxygen availability that leads to a marked improvement in survival, body weight, body temperature, behavior, neuropathology, and disease biomarkers in a genetic mouse model of Leigh syndrome.

TL;DR: The data suggest that reduction of active GCs exclusively in adipose tissue is an important determinant of a favorable metabolic phenotype with respect to energy homeostasis and the metabolic syndrome.