J
Jens C. Brüning
Researcher at Max Planck Society
Publications - 229
Citations - 28649
Jens C. Brüning is an academic researcher from Max Planck Society. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 82, co-authored 214 publications receiving 24536 citations. Previous affiliations of Jens C. Brüning include University of Cologne.
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Journal ArticleDOI
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
Jens C. Brüning,Dinesh Gautam,Deborah J. Burks,Jennifer A. Gillette,Markus Schubert,Paul C. Orban,Rüdiger Klein,Wilhelm Krone,Dirk Müller-Wieland,C. Ronald Kahn +9 more
TL;DR: Mice created with a neuron-specific disruption of the IR gene showed increased food intake, and both male and female mice developed diet-sensitive obesity with increases in body fat and plasma leptin levels, mild insulin resistance, elevated plasma insulin levels, and hypertriglyceridemia.
Journal ArticleDOI
Inactivation of the Fto gene protects from obesity
Julia Fischer,Linda Koch,Linda Koch,Christian Emmerling,Jeanette Vierkotten,Jeanette Vierkotten,Thomas Peters,Thomas Peters,Jens C. Brüning,Jens C. Brüning,Ulrich Rüther +10 more
TL;DR: These experiments provide the first direct demonstration that Fto is functionally involved in energy homeostasis by the control of energy expenditure, and leads to postnatal growth retardation and a significant reduction in adipose tissue and lean body mass.
Journal ArticleDOI
Interleukin-10 signaling in regulatory T cells Is required for suppression of Th17 cell-mediated inflammation
Ashutosh Chaudhry,Robert M. Samstein,Piper R. Treuting,Yuqiong Liang,Marina C. Pils,Jan Michael Heinrich,Robert Smail Jack,F. Thomas Wunderlich,Jens C. Brüning,Werner Müller,Alexander Y. Rudensky +10 more
TL;DR: It is shown that anti-inflammatory interleukin-10 (IL-10), and not proinflammatory IL-6 and IL-23 cytokine signaling, endowed Treg cells with the ability to suppress pathogenic Th17 cell responses.
Journal ArticleDOI
Agouti-related peptide-expressing neurons are mandatory for feeding.
Eva Gropp,Marya Shanabrough,Erzsebet Borok,Allison W. Xu,Ruth Janoschek,Thorsten Buch,Leona Plum,Nina Balthasar,Brigitte Hampel,Ari Waisman,Gregory S. Barsh,Tamas L. Horvath,Jens C. Brüning +12 more
TL;DR: It is demonstrated that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis.
Journal ArticleDOI
Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition
Keertik Fulzele,Ryan C. Riddle,Douglas J. DiGirolamo,Xuemei Cao,Chao Wan,Dongquan Chen,Marie Claude Faugere,Susan Aja,Mehboob A. Hussain,Jens C. Brüning,Jens C. Brüning,Thomas L. Clemens,Thomas L. Clemens +12 more
TL;DR: The results indicate the existence of a bone-pancreas endocrine loop through which insulin signaling in the osteoblasts ensures osteoblast differentiation and stimulates osteocalcin production, which in turn regulates insulin sensitivity and pancreatic insulin secretion.