R. Alan North

TL;DR: Gaetano Di Chiara and Alan North argue that both dopaminergic and non-dopaminergic systems are involved in opiate reward, and that opiate addiction results from adaptive and learning processes involving both positive reinforcing mechanismsrelated to the rewarding properties of opiates and negative reinforcing mechanisms related to the aversive properties of withdrawal in dependent subjects.

TL;DR: The results suggest that alternative splicing gives rise to a large family of functionally diverse, calcium-activated potassium channels, which are probably related to closely related proteins of about 1200 aa.

TL;DR: In this article, it was shown that the burst firing in mammalian neurons is induced by N-methyl-D-aspartate (NMDA), although not by non-NMDA agonists kainate or quisqualate.

TL;DR: It would be trite indeed to say much to this audience of the contributions to pharmacology made by Sir John Gaddum, but his quantitative approaches to the study of drug antagonism have found their way into most textbooks of pharmacology.

TL;DR: The finding that GABA acting at GABAA and GABAB receptors originates from distinct sets of presynaptic fibers suggests that two groups of GABA-containing neurons might be generally distinguishable in the mammalian nervous system.