Showing papers in "Neuroscience Letters in 1992"

TL;DR: In amyloid deposits apo E P, component and glucosaminoglycans may be acting as 'pathological molecular chaperones' as well as a group of unrelated proteins that induce beta-pleated conformation in amyloidsogenic polypeptides.

TL;DR: The localisation of GSK-3 within granular structures in pyramidal cells indicates that G SKS-3 alpha and Gsk-3 beta may have a role in the production of PHF-tau in Alzheimer's disease.

TL;DR: The finding that oxidized glutathione is not decreased in Parkinson's disease suggests that the decrease in reduced glutathion is not exclusively the consequence of neuronal loss in the substantia nigra but may indicate a state of oxidative stress.

TL;DR: The spontaneous discharge and the to K+ channel blockade seen in A beta and A delta primary afferents at the time of the onset of the neuropathic pain syndrome appear to originate in the DRG.

TL;DR: It is reported that rats housed in an enriched environment showed improved performance in the Morris water maze and decreased spontaneous motor activity, suggesting that environmental history of the animal is of importance to induce expression of brain-derived neurotrophic factor in the hippocampus that may promote neuronal changes related to learning and memory.

TL;DR: The results indicate that granule cell hyperexcitability precedes dentate synaptic reorganization and is associated with the selective interneuron loss that is the presumed stimulus for axon sprouting, which indicates that if granules cell axon Sprouting has functional significance, it may be primarily inhibitory, rather than epileptogenic, in nature.

TL;DR: In this paper, an inhibitor of nitric oxide synthase (NOS), N ω - nitro- l -arginine methyl ester ( l -NAME), administered either systemically or intrathecally, blocked the NMDA-induced hyperalgesia.

TL;DR: Examination of the long-term potentiation (LTP) revealed that a brief treatment with the cytokine did not influence LTP, while a long-lasting application of TNF-alpha inhibited LTP in a dose-dependent way in the range of 1-100 nM.

TL;DR: It is concluded that nitric oxide synthase is located in a sub-population of enteric neurons, amongst which are inhibitory motor neurons that supply the circular muscle layer.

TL;DR: This study demonstrates for the first time that time dependent sensory signals detected in the primary auditory cortices are transformed into a time invariant output which is channelled to a functionally specialised region--Wernicke's area.

TL;DR: These findings indicate that ubiquitin-IR inclusions in small neurons of the hippocampus, entorhinal area and neocortex are a characteristic feature of degeneration of non-motor cortex in ALS, and are particularly associated with cognitive impairment and dementia of frontal lobe type.

TL;DR: Results strongly indicate that increased NGF production in CSF is a characteristic feature of the MS inflammatory response.

TL;DR: 5-HT provides a substantial tonic excitatory drive to XII motoneurons and the 5-HT receptors involved are likely to be type 1C or 2, but uncertainty regarding the affinity profiles of the drugs used in in vivo conditions in the cat precludes a definite identification.

TL;DR: The data show that coactivation of D1 and D2 DA receptors is required for LTD in the striatum, and D1/D2 receptor cooperation in the induction of LTD may play a crucial role in the behavioural function of DA and in the therapeutic effects of DA agonists in Parkinson's disease.

TL;DR: Findings indicate that stress can contribute to neuronal degeneration associated with hypogonadal conditions such as aging.

TL;DR: The results indicate that NOS-IR is present in autonomic preganglionic neurons and in selected neurons in the dorsal horn and lamina X, but appears to be absent in motoneurons.

TL;DR: The recent evidence that identifies NADPH diaphorase as nitric oxide synthase raises the possibility that some spinal preganglionic neurons may synthesize nitricoxide.

TL;DR: The finding that GABA acting at GABAA and GABAB receptors originates from distinct sets of presynaptic fibers suggests that two groups of GABA-containing neurons might be generally distinguishable in the mammalian nervous system.

TL;DR: The results in the present study are consistent with the view that nitric oxide (NO) has a mediating role in gastrointestinal neurotransmission.

TL;DR: Data indicate both neuronal and glial localization of IL6 and IL6 receptor and their involvement in an autocrine or paracrine action of the cytokine in centrally regulated functions including neuroendocrine control.

TL;DR: Many Tau-positive glia with paired nuclei and astrocyte type morphology were identified in three brains from patients with progressive supranuclear palsy, suggesting that there is an unusual gliotic reaction in PSP in brain areas which show relatively little neuronal loss.

TL;DR: A highly selective metabotropic EAA agonist was injected into the hippocampus of halothane-anesthetized rats, which resulted in delayed-onset seizures and selective hippocampal neuronal damage that was indirectly mediated by NMDA receptors.

TL;DR: The effect of intracisternal injection of recombinant human TNF alpha (50-50,000 IU) on pial vasoreactivity and blood-brain barrier permeability in newborn piglets and cytokine administration resulted in arterial vasoconstrictions, blood- brain barrier opening and increased Na-fluorescein uptake in brain regions examined in a dose-dependent manner.

TL;DR: The direct evidence of the formation of free radicals supports the hypothesis that free radicals play a role in the pathogenesis of the histological damage during brain ischemia.

TL;DR: Results suggest that activation of the NO system is an important component of the biochemical cascade leading to neurodegeneration produced by NMDA receptors.

TL;DR: It is expected that noxious inputs associated with tissue injury produce a release of aspartate and glutamate within the spinal dorsal horn which by acting at ionotropic and metabotropic excitatory amino acid receptors produce an increase in intracellular messengers such as calcium and diacylglycerol which stimulate protein kinase C.

TL;DR: Thrombin was detected immunohistochemically in brain tissue of Alzheimer's disease patients and age-matched controls, suggesting that thrombin formation from prothrombin probably takes place in AD brain.

TL;DR: The distribution of the messenger RNA encoding the dopamine D5 receptor was determined in the rat brain by in situ hybridization and suggests a novel function in the brain for this subtype of the dopamine receptor.

TL;DR: 5-HT increases the excitability of neonatal HMs via at at least two different postsynaptic mechanisms via at leastTwo different post synapse mechanisms.

TL;DR: Results show that the mesolimbic DA pathway is activated in response to ingestive behavior, and that DA release occurs in the cell body (A10) region as well as in the meslimbicDA nerve terminals.