R M Perlmutter

TL;DR: In this article, an analysis of the subclass distribution of murine antibodies directed against groups A and C streptococcal carbohydrate, alpha-(1 leads to 3) dextran and phosphocholine yields the surprising observation that these carbohydrate antigens stimulate IgG responses largely restricted to the rare IgG3 subclass.

TL;DR: It is demonstrated that mice with the CBA/N phenotype have perferential deficiencies of IgM and IgG3 immunoglobulin expression, both when measured in serum and in cells secreting these isotypes, and that this deficiency is only partially corrected by polyclonal activation of B cells.

TL;DR: It is reported that multiple, closely homologous VH gene segments contribute to the generation of anti-GAC antibodies, and the A/J anti- GAC VH regions and BALB/c anti-inulin VH sequences are 95% homologueous at the protein level and are likely encoded by overlapping VH families.

TL;DR: The picture of substantial structural variation among the antibodies comprising a response of restricted heterogeneity among 19 S and 7 S anti‐α(1→3) dextran (Dex) antibodies has revealed substantial variation of idiotypic and spectrotypic expression between individuals of the same genotype.

TL;DR: These findings indicate that TD-2 properties may also be a characteristic of at least some carbohydrate antigens that can elicit IgG antibody predominantly of the IgG3 class.