D
David E. Briles
Researcher at University of Alabama at Birmingham
Publications - 334
Citations - 21000
David E. Briles is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Streptococcus pneumoniae & Antibody. The author has an hindex of 80, co-authored 332 publications receiving 20194 citations. Previous affiliations of David E. Briles include Washington University in St. Louis & Sanofi Pasteur.
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Journal ArticleDOI
Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae
David E. Briles,Moon H. Nahm,Kenneth R. Schroer,Joseph M. Davie,Phillip J. Baker,John F. Kearney,Raúl G. Barletta +6 more
TL;DR: The antiphosphocholine antibody in normal mouse sera (NMS) provides protection against intravenous infection with encapsulated strain WU2 of type 3 Streptococcus pneumoniae.
Journal Article
Subclass restriction of murine anti-carbohydrate antibodies.
TL;DR: In this article, an analysis of the subclass distribution of murine antibodies directed against groups A and C streptococcal carbohydrate, alpha-(1 leads to 3) dextran and phosphocholine yields the surprising observation that these carbohydrate antigens stimulate IgG responses largely restricted to the rare IgG3 subclass.
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Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae.
TL;DR: Pneumolysin production was reinstated in one of the mutants by transformation with the cloned pneumolysin gene, with the concomitant loss of erythromycin resistance; the virulence in mice of this isolate was indistinguishable from that of S. pneumoniae D39, a virulent type 2 strain.
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Diversity of PspA: Mosaic Genes and Evidence for Past Recombination in Streptococcus pneumoniae
TL;DR: The extensive recombination which generated the mosaic pattern seen in the pspA locus suggests that natural selection has operated in the history of this gene locus and underscores the likelihood that PspA may be important in the interaction between the pneumococcus and its human host.
Journal ArticleDOI
Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae.
David E. Briles,Eddie Ades,James C. Paton,Jacquelyn S. Sampson,George M. Carlone,Robert C. Huebner,Anni Virolainen,Edwin Swiatlo,Susan K. Hollingshead +8 more
TL;DR: Results indicate that PspA and PsaA may be useful for the elicitation of herd immunity in humans and their inclusion in a mucosal vaccine may enable such a vaccine to prevent invasive disease as well as carriage.