R.P.J. Oude Elferink

TL;DR: This work focuses on three topics: ABC transporters transporting drugs (xenotoxins) and drug conjugates, and a rapidly increasing number of ABC Transporters found to play a role in lipid transport.

TL;DR: It is concluded that the mdr2 P-glycoprotein has an essential role in the secretion of phosphatidylcholine into bile and hypothesize that it may be a phospholipid transport protein or phospholIPid flippase.

TL;DR: It is shown that cMOAT causes transport of the organic anions S-(2,4-dinitrophenyl)-glutathione, the glutathione conjugate of ethacrynic acid, and S-(PGA1)-gluten, a substrate not shown to be transported by organic anion transporters previously.

TL;DR: It is demonstrated that depletion of intracellular glutathione by DL-buthionine (S,R)-sulfoximine results in a complete reversal of resistance to doxorubicin, daunorubICin, vincristine, and VP-16 in lung carcinoma cells transfected with a MRP cDNA expression vector, and this results support the hypothesis that MRP functions as a glutATHione S-conjugate carrier.

TL;DR: Probenecid and sulfinpyrazone may be useful lead compounds for the development of clinical reversal agents specific for MRP-mediated drug resistance, as determined by immunocytochemistry and electron microscopy.