R
Rabbab Oun
Researcher at Strathclyde Institute of Pharmacy and Biomedical Sciences
Publications - 9
Citations - 2883
Rabbab Oun is an academic researcher from Strathclyde Institute of Pharmacy and Biomedical Sciences. The author has contributed to research in topics: Cisplatin & Drug delivery. The author has an hindex of 8, co-authored 9 publications receiving 2211 citations. Previous affiliations of Rabbab Oun include University of Strathclyde & University of Glasgow.
Papers
More filters
Journal ArticleDOI
The status of platinum anticancer drugs in the clinic and in clinical trials.
TL;DR: The status of platinum anticancer drugs currently approved for use, those undergoing clinical trials and those discontinued during clinical trials are updated, and the results in the context of where the field will develop over the next decade are discussed.
Journal ArticleDOI
The side effects of platinum-based chemotherapy drugs: a review for chemists
TL;DR: Patients are commonly co-prescribed additional non-chemotherapy based drugs to treat the side effects which can include antiemetics, antibiotics and myeloid growth factors, mannitol, propafenone, saline hyperhydration, magnesium supplements, monoclonal antibody cytokine blockers, and antioxidants.
Journal ArticleDOI
The potential of cucurbit[n]urils in drug delivery
TL;DR: The potential use of cucurbiturils in drug delivery in the context of getting a new drug into clinical trials is examined and what further research is needed in this area is discussed.
Journal ArticleDOI
The ex vivo neurotoxic, myotoxic and cardiotoxic activity of cucurbituril-based macrocyclic drug delivery vehicles
TL;DR: The results show continued potential of cucurbiturils as drug delivery vehicles for the reduction of the side effects associated with platinum-based chemotherapy, and a relative lack of toxicity displayed by these macrocycles in whole animal acute systemic toxicity studies.
Journal ArticleDOI
Cucurbit[7]uril encapsulated cisplatin overcomes cisplatin resistance via a pharmacokinetic effect
Jane A. Plumb,Balaji Venugopal,Rabbab Oun,Rabbab Oun,Natividad Gomez-Roman,Yoshiyuki Kawazoe,Natarajan Sathiyamoorthy Venkataramanan,Nial J. Wheate +7 more
TL;DR: The results provide the first example of overcoming drug resistance via a purely pharmacokinetic effect rather than drug design or better tumour targeting, and demonstrate that in vitro assays are no longer as important in screening advanced systems of drug delivery.