R
Rachel Morano
Researcher at University of Cincinnati
Publications - 27
Citations - 504
Rachel Morano is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Chronic stress & Prefrontal cortex. The author has an hindex of 9, co-authored 27 publications receiving 331 citations. Previous affiliations of Rachel Morano include University of Cincinnati Academic Health Center & University of Michigan.
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Journal ArticleDOI
Chronic Stress Increases Prefrontal Inhibition: A Mechanism for Stress-Induced Prefrontal Dysfunction
Jessica M. McKlveen,Rachel Morano,Maureen Fitzgerald,Sandra Zoubovsky,Sarah N. Cassella,Jessie R. Scheimann,Sriparna Ghosal,Parinaz Mahbod,Benjamin A. Packard,Brent Myers,Mark L. Baccei,James P. Herman +11 more
TL;DR: The data suggest that chronic stress increases synaptic inhibition onto prefrontal glutamatergic output neurons, limiting the influence of the prefrontal cortex in control of stress reactivity and behavior.
Journal ArticleDOI
Adolescent chronic stress causes hypothalamo-pituitary-adrenocortical hypo-responsiveness and depression-like behavior in adult female rats.
TL;DR: It is demonstrated that exposure to chronic stress in adolescence is sufficient to induce lasting changes in neuroendocrine drive and behavior, potentially altering the developmental trajectory of stress circuits as female rats age into adulthood.
Journal ArticleDOI
Adolescent environmental enrichment prevents behavioral and physiological sequelae of adolescent chronic stress in female (but not male) rats
Brittany L. Smith,Rachel Morano,Yvonne M. Ulrich-Lai,Brent Myers,Matia B. Solomon,James P. Herman +5 more
TL;DR: It is found that environmental enrichment given during the adolescent period prevented the chronic stress-induced transition to passive coping in the FST and reversed decreases in peak adrenocortical responsiveness observed in adult females.
Journal ArticleDOI
Vesicular Glutamate Transporter 1 Knockdown in Infralimbic Prefrontal Cortex Augments Neuroendocrine Responses to Chronic Stress in Male Rats.
Brent Myers,Jessica M. McKlveen,Rachel Morano,Yvonne M. Ulrich-Lai,Matia B. Solomon,Steven P. Wilson,James P. Herman +6 more
TL;DR: The results suggest that IL glutamate output inhibits HPA responses to acute stress and restrains corticosterone secretion during chronic stress, possibly at the level of the adrenal.
Journal ArticleDOI
Functional disruption of stress modulatory circuits in a model of temporal lobe epilepsy
Aynara C. Wulsin,Ana Franco-Villanueva,Christian Romancheck,Rachel Morano,Brittany L. Smith,Benjamin A. Packard,Steve C. Danzer,James P. Herman +7 more
TL;DR: It is demonstrated that epileptic mice develop HPA axis hyperactivity and exhibit behavioral dysfunction, which may underlie pronounced endocrine dysfunction and comorbid psychopathologies seen in temporal lobe epilepsy.