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Aynara C. Wulsin
Researcher at University of Cincinnati
Publications - 14
Citations - 1536
Aynara C. Wulsin is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Corticosterone & Glucocorticoid receptor. The author has an hindex of 10, co-authored 14 publications receiving 1060 citations. Previous affiliations of Aynara C. Wulsin include Cincinnati Children's Hospital Medical Center & Colby College.
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Regulation of the hypothalamic-pituitary-adrenocortical stress response
James P. Herman,Jessica M. McKlveen,Sriparna Ghosal,Brittany L. Kopp,Aynara C. Wulsin,Ryan Makinson,Jessie R. Scheimann,Brent Myers +7 more
TL;DR: Chronic stress-induced activation of the HPA axis takes many forms (chronic basal hypersecretion, sensitized stress responses, and even adrenal exhaustion), with manifestation dependent upon factors such as stressor chronicity, intensity, frequency, and modality.
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Mifepristone Decreases Depression-Like Behavior and Modulates Neuroendocrine and Central Hypothalamic-Pituitary-Adrenocortical Axis Responsiveness to Stress
TL;DR: The data suggest that drugs targeting the glucocorticoid receptor may ameliorate stress dysfunction associated with depressive illness, and perhaps HPA dampening properties of RU486 are related to alterations in key limbic circuits mediating CNS stress responses.
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Deletion of forebrain glucocorticoid receptors impairs neuroendocrine stress responses and induces depression-like behavior in males but not females.
Matia B. Solomon,Amy R. Furay,Kenneth R. Jones,Amy E.B. Packard,Benjamin A. Packard,Aynara C. Wulsin,James P. Herman +6 more
TL;DR: Overall the findings indicate a marked sex difference in the function of forebrain GR on HPA axis regulation and depression-like behaviors, and may have implications for therapeutic approaches using GR-modulating drugs.
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Neuroendocrine Function After Hypothalamic Depletion of Glucocorticoid Receptors in Male and Female Mice
Matia B. Solomon,Matthew C. Loftspring,Annette D. de Kloet,Sriparna Ghosal,Ryan Jankord,Jonathan N. Flak,Aynara C. Wulsin,Eric G. Krause,Rong Zhang,Taylor Rice,Jessica M. McKlveen,Brent Myers,Jeffrey G. Tasker,James P. Herman +13 more
TL;DR: Results reveal pronounced sex differences in the PVN GR dependence of acute stress feedback regulation of HPA axis function and indicate that glucocorticoid control of H PA axis responses after chronic stress operates via a PVN-independent mechanism.
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The Selective Glucocorticoid Receptor Antagonist CORT 108297 Decreases Neuroendocrine Stress Responses and Immobility in the Forced Swim Test
Matia B. Solomon,Aynara C. Wulsin,Taylor Rice,Dayna Wick,Brent Myers,Jessica M. McKlveen,Jonathan N. Flak,Yvonne M. Ulrich-Lai,James P. Herman +8 more
TL;DR: The data suggest that CORT 108297 may be an attractive alternative for mitigating neuroendocrine and behavioral states associated with excess glucocorticoid secretion and also highlight dissociation between corticosterone responses and immobility in the FST.