Rafael Elias Marques

TL;DR: Targeting HIF-1α-induced changes in monocyte metabolism by SARS-CoV-2 infection directly inhibit T cell response and reduce epithelial cell survival, and may have great therapeutic potential for the development of novel drugs to treat COVID-19.

TL;DR: In line with its in vitro anti-ZIKV activity, 7DMA reduced viremia and delayed virus-induced morbidity and mortality in infected mice, which validates this small animal model to assess the in vivo efficacy of novel ZIKV inhibitors.

TL;DR: Overall, it is not likely that specific targeting of CCL5 will result in new adjunct strategies for the treatment of infectious diseases with a major inflammatory component, but targeting CCR5 could result in novel therapies for chronic inflammatory diseases, where it may decrease inflammatory responses and fibrosis, and certain solid tumors,where it may have a role in angiogenesis.

TL;DR: It is revealed that liver injury due to acetaminophen overdose led to a directional migration of neutrophils to DNA‐rich areas, where they exhibit an active patrolling behavior, which is a novel feature of DILI pathogenesis.

TL;DR: A mouse model of developmental disruption induced by ZikV hematogenic infection is presented, providing a developmental window of opportunity for ZIKV-induced teratogenesis encompassing early gastrulation, neurulation and early organogenesis stages.