P
Pedro Marques
Researcher at Universidade Federal de Minas Gerais
Publications - 81
Citations - 1693
Pedro Marques is an academic researcher from Universidade Federal de Minas Gerais. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 18, co-authored 53 publications receiving 1213 citations. Previous affiliations of Pedro Marques include Rega Institute for Medical Research.
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Journal ArticleDOI
Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure.
Pedro Marques,Sylvia S. Amaral,Daniele Araújo Pires,Laura L. Nogueira,Frederico Marianetti Soriani,Braulio H.F. Lima,Gabriel Augusto Oliveira Lopes,Remo Castro Russo,Thiago Vinícius Ávila,Juliana Gil Melgaço,André G. Oliveira,Marcelo Alves Pinto,Cristiano Xavier Lima,Ana M. de Paula,Denise Carmona Cara,Maria de Fátima Leite,Mauro M. Teixeira,Gustavo B. Menezes +17 more
TL;DR: Chemokines and mitochondrial products collaborate in neutrophil‐mediated injury and systemic inflammation during acute liver failure and the release of necrotic products into the circulation may trigger a systemic inflammatory response and remote lung injury.
Journal ArticleDOI
Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice
Bruna Araújo David,Rafael M. Rezende,Maísa Mota Antunes,Mônica Morais Santos,Maria Alice Freitas Lopes,Ariane Barros Diniz,Rafaela Vaz Sousa Pereira,Sarah Cozzer Marchesi,Débora Moreira Alvarenga,Brenda Naemi Nakagaki,Alan Moreira de Araujo,Daniela Reis,Renata Monti Rocha,Pedro Marques,Woo-Yong Lee,Justin F. Deniset,Pei Xiong Liew,Stephen Rubino,Laura M. Cox,Vanessa Pinho,Thiago M. Cunha,Gabriel Fernandes,André G. Oliveira,Mauro M. Teixeira,Paul Kubes,Gustavo B. Menezes +25 more
TL;DR: In studies of hepatic phagocyte depletion in mice, it is found that myeloid precursors can differentiate into liver macrophages and dendritic cells, which each localize to distinct tissue compartments.
Journal ArticleDOI
Hepatic DNA deposition drives drug‐induced liver injury and inflammation in mice
Pedro Marques,André G. Oliveira,Rafaela Vaz Sousa Pereira,Bruna Araújo David,Lindisley Ferreira Gomides,Adriana Machado Saraiva,Daniele Araújo Pires,Júlia Tosta Novaes,Daniel O. Patricio,Daniel Cisalpino,Zélia Menezes-Garcia,W. Matthew Leevy,Sarah Chapman,GermánArturo Mahecha,Rafael Elias Marques,Rodrigo Guabiraba,Vicente de Paulo Martins,Danielle G. Souza,Daniel S. Mansur,Mauro Martins Teixeira,M. Fatima Leite,Gustavo B. Menezes +21 more
TL;DR: It is revealed that liver injury due to acetaminophen overdose led to a directional migration of neutrophils to DNA‐rich areas, where they exhibit an active patrolling behavior, which is a novel feature of DILI pathogenesis.
Journal ArticleDOI
Neutrophils: a cornerstone of liver ischemia and reperfusion injury
Thiago Henrique Caldeira de Oliveira,Thiago Henrique Caldeira de Oliveira,Pedro Marques,Paul Proost,Mauro M. Teixeira +4 more
TL;DR: This review summarizes recent advances in neutrophil-mediated liver damage, and its application to liver IRI, and basic mechanisms of activation of neutrophils and their unique mechanisms of recruitment into the liver vasculature are discussed.
Journal ArticleDOI
Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria
Bruno Coelho Rocha,Bruno Coelho Rocha,Bruno Coelho Rocha,Pedro Marques,Fabiana M. S. Leoratti,Caroline Junqueira,Dhelio Batista Pereira,Lis Ribeiro do Valle Antonelli,Gustavo B. Menezes,Douglas T. Golenbock,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli +12 more
TL;DR: In this article, the authors found that neutrophils from malaria patients are highly activated, as indicated by a strong type I interferon transcriptional signature, increased expression of surface activation markers, enhanced release of reactive oxygen species and myeloperoxidase, and a high frequency of low-density granulocytes.