L
Licio A. Velloso
Researcher at State University of Campinas
Publications - 426
Citations - 20401
Licio A. Velloso is an academic researcher from State University of Campinas. The author has contributed to research in topics: Insulin & Insulin receptor. The author has an hindex of 71, co-authored 391 publications receiving 17772 citations. Previous affiliations of Licio A. Velloso include University of São Paulo.
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Journal ArticleDOI
Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus
Cláudio T. De Souza,Eliana P. Araújo,Silvana Bordin,Rika Ashimine,Ricardo de Lima Zollner,Antonio Carlos Boschero,Mario J.A. Saad,Licio A. Velloso +7 more
TL;DR: It is concluded that HL feeding induces a local proinflammatory status in the hypothalamus, which results in impaired anorexigenic insulin signaling, which leads to a reduced caloric intake and weight loss.
Journal ArticleDOI
Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity.
Marciane Milanski,Giovanna R. Degasperi,Andressa Coope,Joseane Morari,Raphael G. P. Denis,Dennys E. Cintra,Daniela Miti Lemos Tsukumo,Gabriel Forato Anhê,Maria Esméria Corezola do Amaral,Hilton Kenji Takahashi,Rui Curi,Helena C. F. Oliveira,José B.C. Carvalheira,Silvana Bordin,Mario J.A. Saad,Licio A. Velloso +15 more
TL;DR: Toll-like receptor 4 acts as a predominant molecular target for saturated fatty acids in the hypothalamus, triggering the intracellular signaling network that induces an inflammatory response, and determines the resistance to anorexigenic signals.
Journal ArticleDOI
Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance
Daniela Miti Lemos Tsukumo,Marco Antonio de Carvalho-Filho,José B.C. Carvalheira,Patrícia O. Prada,Sandro M. Hirabara,André Almeida Schenka,Eliana P. Araújo,José Vassallo,Rui Curi,Licio A. Velloso,Mario J.A. Saad +10 more
TL;DR: It is shown that C3H/HeJ mice, which have a loss-of-function mutation in TLR4, are protected against the development of diet-induced obesity and a potential target for the therapy of these highly prevalent medical conditions.
Journal ArticleDOI
Endoplasmic reticulum stress, obesity and diabetes
TL;DR: Ways in which ER stress operates as a common molecular pathway in the pathogenesis of obesity and diabetes are discussed.
Journal ArticleDOI
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis
Ana Campos Codo,Gustavo Gastão Davanzo,Lauar de Brito Monteiro,Gabriela Fabiano de Souza,Stéfanie Primon Muraro,João Victor Virgilio-da-Silva,Juliana Silveira Prodonoff,Victor Corasolla Carregari,Carlos Alberto Oliveira de Biagi Junior,Fernanda Crunfli,Jeffersson Leandro Jimenez Restrepo,Pedro Henrique Vendramini,Guilherme Reis-de-Oliveira,Karina Bispo dos Santos,Daniel A. Toledo-Teixeira,Pierina Lorencini Parise,M. C. Martini,Rafael Elias Marques,Helison R. Carmo,Alexandre Borin,Lais D. Coimbra,Vinícius O. Boldrini,Natalia S Brunetti,André Schwambach Vieira,Eli Mansour,Raisa G. Ulaf,A. F. Bernardes,Thyago A. Nunes,Luciana C. Ribeiro,Andre C. Palma,Marcus V. Agrela,Maria Luiza Moretti,Andrei C. Sposito,Fabrício Bíscaro Pereira,Licio A. Velloso,Marco Aurélio Ramirez Vinolo,André Damasio,José Luiz Proença-Módena,Robson Francisco Carvalho,Marcelo A. Mori,Daniel Martins-de-Souza,Helder I. Nakaya,Alessandro S. Farias,Pedro M. Moraes-Vieira +43 more
TL;DR: Targeting HIF-1α-induced changes in monocyte metabolism by SARS-CoV-2 infection directly inhibit T cell response and reduce epithelial cell survival, and may have great therapeutic potential for the development of novel drugs to treat COVID-19.