E
Ernest Giralt
Researcher at University of Barcelona
Publications - 560
Citations - 19079
Ernest Giralt is an academic researcher from University of Barcelona. The author has contributed to research in topics: Peptide & Peptide synthesis. The author has an hindex of 69, co-authored 554 publications receiving 17558 citations. Previous affiliations of Ernest Giralt include Autonomous University of Madrid & University of Minnesota.
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Chemical Approaches to the Synthesis of Peptides and Proteins
TL;DR: This chapter discusses the techniques used in the synthesis of Peptide Library Synthesis, as well as some of the approaches taken in the Synthesis of Large Peptides and Proteins Convergent Solid-Phase Peptid Synthesis.
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Perspectives on NMR in drug discovery: a technique comes of age
Maurizio Pellecchia,Ivano Bertini,David Cowburn,Claudio Dalvit,Ernest Giralt,Wolfgang Jahnke,Thomas L. James,Steve W. Homans,Horst Kessler,Claudio Luchinat,Bernd Meyer,Hartmut Oschkinat,Jeff Peng,Harald Schwalbe,Gregg Siegal +14 more
TL;DR: Some of the major applications of NMR in drug discovery, focusing on hit and lead generation, are highlighted, and a critical analysis of its current and potential utility is provided.
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Molecular recycling within amyloid fibrils.
Natàlia Carulla,Gemma L. Caddy,Damien Hall,Jesús Zurdo,Margarida Gairí,Miguel Feliz,Ernest Giralt,Carol V. Robinson,Christopher M. Dobson +8 more
TL;DR: Investigation of the nature of the amyloid structure by monitoring hydrogen/deuterium exchange in fibrils formed from an SH3 domain using a combination of nuclear magnetic resonance spectroscopy and electrospray ionization mass spectrometry reveals that exchange is dominated by a mechanism of dissociation and re-association that results in the recycling of molecules within the fibril population.
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Mechanism of action of and resistance to quinolones
TL;DR: These plasmid‐mediated mechanisms of resistance confer low levels of resistance but provide a favourable background in which selection of additional chromosomally encoded quinolone resistance mechanisms can occur.
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Peptide and amide bond-containing dendrimers.
TL;DR: Dendrimer Synthesis: Types I and II: Covalent Peptide Dendrimers Based on Amino Acids as Building Blocks 1668 3.1.