R
Rafael Malagoli Rocha
Researcher at Federal University of São Paulo
Publications - 120
Citations - 4911
Rafael Malagoli Rocha is an academic researcher from Federal University of São Paulo. The author has contributed to research in topics: Cancer & Vulvar cancer. The author has an hindex of 28, co-authored 119 publications receiving 4171 citations. Previous affiliations of Rafael Malagoli Rocha include Universidade Federal de Minas Gerais.
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PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
Valerie S. LeBleu,Joyce T. O’Connell,Karina N. Gonzalez Herrera,Harriet Wikman,Klaus Pantel,Marcia C. Haigis,Fernanda Machado de Carvalho,Aline Santos Damascena,Ludmilla Thomé Domingos Chinen,Rafael Malagoli Rocha,John M. Asara,Raghu Kalluri +11 more
TL;DR: It is reported that migratory/invasive cancer cells specifically favour mitochondrial respiration and increased ATP production, and mitochondrial biogenesis and respiration induced by PGC-1α are also essential for functional motility of cancer cells and metastasis.
Journal ArticleDOI
Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway
Vesselina G. Cooke,Valerie S. LeBleu,Doruk Keskin,Zainab Khan,Joyce T. O’Connell,Yingqi Teng,Michael Duncan,Liang Xie,Genta Maeda,Sylvia Vong,Hikaru Sugimoto,Rafael Malagoli Rocha,Aline Santos Damascena,Ricardo R. Brentani,Raghu Kalluri,Raghu Kalluri,Raghu Kalluri +16 more
TL;DR: In this paper, pericyte depletion was associated with increased hypoxia, epithelial-to-mesenchymal transition (EMT), and Met receptor activation in breast cancer patients.
Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway
Vesselina G. Cooke,Valerie S. LeBleu,Doruk Keskin,Zainab Khan,Joyce T. O’Connell,Yingqi Teng,Michael Duncan,Liang Xie,Genta Maeda,Sylvia Vong,Hikaru Sugimoto,Rafael Malagoli Rocha,Aline Santos Damascena,Ricardo R. Brentani,Raghu Kalluri,Raghu Kalluri,Raghu Kalluri +16 more
TL;DR: This study suggests that pericytes within the primary tumor microenvironment likely serve as important gatekeepers against cancer progression and metastasis.
Journal ArticleDOI
VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization
Joyce T. O’Connell,Hikaru Sugimoto,Vesselina G. Cooke,Brian MacDonald,Ankit I. Mehta,Valerie S. LeBleu,Rajan Dewar,Rafael Malagoli Rocha,Ricardo R. Brentani,Murray B. Resnick,Eric G. Neilson,Michael Zeisberg,Raghu Kalluri +12 more
TL;DR: A crucial role for local S100A4+ fibroblasts in providing the permissive “soil” for metastatic colonization, a challenging step in the metastatic cascade is demonstrated.
Journal ArticleDOI
Erratum: PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis (Nature Cell Biology (2014) 16 (992-1003))
Valerie S. LeBleu,Joyce T. O’Connell,Karina N. Gonzalez Herrera,Harriet Wikman,Klaus Pantel,Marcia C. Haigis,Fernanda Machado de Carvalho,Aline Santos Damascena,Ludmilla Thomé Domingos Chinen,Rafael Malagoli Rocha,John M. Asara,Raghu Kalluri +11 more
TL;DR: Corrigendum: PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.