H
Hikaru Sugimoto
Researcher at Harvard University
Publications - 36
Citations - 8799
Hikaru Sugimoto is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Type IV collagen. The author has an hindex of 28, co-authored 36 publications receiving 7934 citations. Previous affiliations of Hikaru Sugimoto include Boys Town & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury
Michael Zeisberg,Jun-ichi Hanai,Hikaru Sugimoto,Tadanori Mammoto,David M. Charytan,Frank Strutz,Raghu Kalluri +6 more
TL;DR: It is reported that BMP-7 reverses TGF-β1–induced epithelial-to-mesenchymal transition (EMT) by reinduction of E-cadherin, a key epithelial cell adhesion molecule, which provides evidence of cross talk between B MP-7 and TGF -β1 in the regulation of EMT in health and disease.
Journal ArticleDOI
Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition
TL;DR: It is demonstrated that endothelial cells also contribute to the emergence of fibroblasts during kidney fibrosis via the process of endothelial-to-mesenchymal transition (EndMT), and it is suggested that targeting EndMT might have therapeutic potential.
Journal ArticleDOI
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.
Jochen Reiser,Krishna R. Polu,Clemens C. Möller,Peter Kenlan,Mehmet M. Altintas,Changli Wei,Christian Faul,Stephanie Herbert,Ivan Villegas,Carmen Avila-Casado,Mary McGee,Hikaru Sugimoto,Dennis Brown,Raghu Kalluri,Peter Mundel,Paula Smith,David E. Clapham,Martin R. Pollak +17 more
TL;DR: It is shown that the canonical transient receptor potential 6 (TRPC6) ion channel is expressed in podocytes and is a component of the glomerular slit diaphragm.
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Erratum to Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival [Cancer Cell 25, 719-734; (2014)]
Berna C. Özdemir,Tsvetelina Pentcheva-Hoang,Julienne L. Carstens,Xiaofeng Zheng,Chia Chin Wu,Tyler R. Simpson,Hanane Laklai,Hikaru Sugimoto,Christoph Kahlert,Sergey V. Novitskiy,Ana De Jesus-Acosta,Padmanee Sharma,Pedram Heidari,Umar Mahmood,Lynda Chin,Harold L. Moses,Valerie M. Weaver,Anirban Maitra,James P. Allison,Valerie S. LeBleu,Raghu Kalluri +20 more
TL;DR: This research highlights the need to understand more fully the role of language in the development of post-traumatic stress disorder and the role that language can play in the recovery.
Journal ArticleDOI
Induction of B7-1 in podocytes is associated with nephrotic syndrome
Jochen Reiser,Jochen Reiser,Gero von Gersdorff,Martin Loos,Jun Oh,Katsuhiko Asanuma,Laura Giardino,Maria Pia Rastaldi,Novella Calvaresi,Haruko Watanabe,Karin Schwarz,Christian Faul,Matthias Kretzler,Anne Davidson,Hikaru Sugimoto,Raghu Kalluri,Arlene H. Sharpe,Jordan A. Kreidberg,Peter Mundel +18 more
TL;DR: Upregulation of B7-1 in podocytes may contribute to the pathogenesis of proteinuria by disrupting the glomerular filter and provides a novel molecular target to tackle proteinuric kidney diseases.