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Showing papers by "Rafael Molina published in 2020"


Journal ArticleDOI
TL;DR: A patch-wise predictive model based on convolutional neural networks able to determine the presence of cancerous patterns based on the Gleason grading system and reaches the level of fine-tuned state-of-the-art architectures in a patient-based four groups cross validation.

50 citations


Journal ArticleDOI
TL;DR: This paper introduces the use of deep Gaussian Processes (DGPs) for bio-geo-physical model inversion, and provides empirical evidence of performance for the estimation of surface temperature and dew point temperature from infrared sounding data, as well as for the prediction of chlorophyll content, inorganic suspended matter, and coloured dissolved matter from multispectral data acquired by the Sentinel-3 OLCI sensor.
Abstract: Parameter retrieval and model inversion are key problems in remote sensing and Earth observation. Currently, different approximations exist: a direct, yet costly, inversion of radiative transfer models (RTMs); the statistical inversion with in situ data that often results in problems with extrapolation outside the study area; and the most widely adopted hybrid modeling by which statistical models, mostly nonlinear and non-parametric machine learning algorithms, are applied to invert RTM simulations. We will focus on the latter. Among the different existing algorithms, in the last decade kernel based methods, and Gaussian Processes (GPs) in particular, have provided useful and informative solutions to such RTM inversion problems. This is in large part due to the confidence intervals they provide, and their predictive accuracy. However, RTMs are very complex, highly nonlinear, and typically hierarchical models, so that very often a single (shallow) GP model cannot capture complex feature relations for inversion. This motivates the use of deeper hierarchical architectures, while still preserving the desirable properties of GPs. This paper introduces the use of deep Gaussian Processes (DGPs) for bio-geo-physical model inversion. Unlike shallow GP models, DGPs account for complicated (modular, hierarchical) processes, provide an efficient solution that scales well to big datasets, and improve prediction accuracy over their single layer counterpart. In the experimental section, we provide empirical evidence of performance for the estimation of surface temperature and dew point temperature from infrared sounding data, as well as for the prediction of chlorophyll content, inorganic suspended matter, and coloured dissolved matter from multispectral data acquired by the Sentinel-3 OLCI sensor. The presented methodology allows for more expressive forms of GPs in big remote sensing model inversion problems.

28 citations


Journal ArticleDOI
TL;DR: In this paper, the pseudo-inverse image formation model is used as part of the network architecture in conjunction with perceptual losses and a smoothness constraint that eliminates the artifacts originating from these perceptual losses.

18 citations


Journal ArticleDOI
TL;DR: A framework that achieves both objectives depending on the number of stains used to mathematically decompose the scanned image is proposed and compared to classical and state-of-the-art methods for histopathological blind image color deconvolution and prostate cancer classification.

11 citations


Journal ArticleDOI
TL;DR: In this paper, three efficient new blind color deconvolution methods are proposed which provide automated procedures to estimate all the model parameters in the problem and a comparison with classical and current state-of-the-art color deconVolution algorithms has been carried out demonstrating the superiority of the proposed approach.
Abstract: Most whole-slide histological images are stained with two or more chemical dyes. Slide stain separation or color deconvolution is a crucial step within the digital pathology workflow. In this paper, the blind color deconvolution problem is formulated within the Bayesian framework. Starting from a multi-stained histological image, our model takes into account both spatial relations among the concentration image pixels and similarity between a given reference color-vector matrix and the estimated one. Using Variational Bayes inference, three efficient new blind color deconvolution methods are proposed which provide automated procedures to estimate all the model parameters in the problem. A comparison with classical and current state-of-the-art color deconvolution algorithms using real images has been carried out demonstrating the superiority of the proposed approach.

10 citations


Journal ArticleDOI
TL;DR: This work proposes a parameter-free Gaussian PSF model in which the all-in-focus image together with both the depth map and sampling distances in image plane are estimated from the image sequence automatically, without knowledge on the z-stack acquisition.
Abstract: Due to their limited depth of field, conventional brightfield microscopes cannot image thick specimens entirely in focus. A common way to obtain an all-in-focus image is to acquire a z-stack of images by optically sectioning the specimen and then apply a multi-focus fusion method. Unfortunately, for undersampled image stacks, fusion methods cannot remove the blur in regions where the in-focus position is between two optical sections. In this work, we propose a parameter-free Gaussian PSF model in which the all-in-focus image together with both the depth map and sampling distances in image plane are estimated from the image sequence automatically, without knowledge on the z-stack acquisition. In a maximum a posteriori framework, an iteratively reweighted least squares method is used to estimate the image and an adaptive scaled gradient descent method is utilized to estimate the depth map and sampling distances efficiently. Experiments on synthetic and real data demonstrate that the proposed method outperforms the current state-of-the-art, mitigating fusion artifacts and recovering sharper edges.

4 citations


Proceedings ArticleDOI
01 Oct 2020
TL;DR: This paper proposes the use of Super Gaussian (SG) priors for each stain concentration together with the similarity to a given reference matrix for the color vectors to automatically estimate all the latent variables in digital histopathological blind image color deconvolution.
Abstract: Color deconvolution aims at separating multi-stained images into single stained ones. In digital histopathological images, true stain color vectors vary between images and need to be estimated to obtain stain concentrations and separate stain bands. These band images can be used for image analysis purposes and, once normalized, utilized with other multi-stained images (from different laboratories and obtained using different scanners) for classification purposes. In this paper we propose the use of Super Gaussian (SG) priors for each stain concentration together with the similarity to a given reference matrix for the color vectors. Variational inference and an evidence lower bound are utilized to automatically estimate all the latent variables. The proposed methodology is tested on real images and compared to classical and state-of-the-art methods for histopathological blind image color deconvolution.

4 citations


Journal ArticleDOI
16 Sep 2020-Sensors
TL;DR: A variational Bayesian methodology for pansharpening that uses the sensor characteristics to model the observation process and Super-Gaussian sparse image priors on the expected characteristics of the panshARPened image is proposed.
Abstract: Pansharpening is a technique that fuses a low spatial resolution multispectral image and a high spatial resolution panchromatic one to obtain a multispectral image with the spatial resolution of the latter while preserving the spectral information of the multispectral image. In this paper we propose a variational Bayesian methodology for pansharpening. The proposed methodology uses the sensor characteristics to model the observation process and Super-Gaussian sparse image priors on the expected characteristics of the pansharpened image. The pansharpened image, as well as all model and variational parameters, are estimated within the proposed methodology. Using real and synthetic data, the quality of the pansharpened images is assessed both visually and quantitatively and compared with other pansharpening methods. Theoretical and experimental results demonstrate the effectiveness, efficiency, and flexibility of the proposed formulation.

3 citations


Posted Content
01 Dec 2020-viXra
TL;DR: This work presents a novel approach to PMMWI classification based on the use of Gaussian Processes for large data sets that relies on linear approximations to kernel functions through random Fourier features and model hyperparameters are learned within a variational Bayes inference scheme.
Abstract: Passive Millimeter Wave Images (PMMWIs) are being increasingly used to identify and localize objects concealed under clothing. Taking into account the quality of these images and the unknown position, shape, and size of the hidden objects, large data sets are required to build successful classification/detection systems. Kernel methods, in particular Gaussian Processes (GPs), are sound, flexible, and popular techniques to address supervised learning problems. Unfortunately, their computational cost is known to be prohibitive for large scale applications. In this work, we present a novel approach to PMMWI classification based on the use of Gaussian Processes for large data sets. The proposed methodology relies on linear approximations to kernel functions through random Fourier features. Model hyperparameters are learned within a variational Bayes inference scheme. Our proposal is well suited for real-time applications, since its computational cost at training and test times is much lower than the original GP formulation. The proposed approach is tested on a unique, large, and real PMMWI database containing a broad variety of sizes, types, and locations of hidden objects.

1 citations