P
Pavel Janscak
Researcher at University of Zurich
Publications - 53
Citations - 3460
Pavel Janscak is an academic researcher from University of Zurich. The author has contributed to research in topics: Helicase & DNA repair. The author has an hindex of 30, co-authored 48 publications receiving 3038 citations. Previous affiliations of Pavel Janscak include Academy of Sciences of the Czech Republic & University of Toronto.
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Journal ArticleDOI
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.
Yiduo Hu,Steven Raynard,Michael G. Sehorn,Michael G. Sehorn,Xincheng Lu,Wendy Bussen,Lu Zheng,Jeremy M. Stark,Ellen Barnes,Peter Chi,Pavel Janscak,Maria Jasin,Hannes Vogel,Patrick Sung,Guangbin Luo +14 more
TL;DR: This work shows that deletion of Recql5 in mice results in cancer susceptibility and identifies RECQL5 as an important tumor suppressor that may act by preventing inappropriate HR events via Rad51 presynaptic filament disruption.
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Replication Fork Reversal Triggers Fork Degradation in BRCA2-defective Cells
Sofija Mijic,Ralph Zellweger,Nagaraja Chappidi,Matteo Berti,Kurt Jacobs,Karun Mutreja,Sebastian Ursich,Arnab Ray Chaudhuri,Arnab Ray Chaudhuri,André Nussenzweig,Pavel Janscak,Massimo Lopes +11 more
TL;DR: It is proposed that BRCA2 is dispensable for RAD51-mediated fork reversal, but assembles stable RAD51 nucleofilaments on regressed arms, to protect them from degradation, and revealed how HR factors cooperate in fork remodeling.
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Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin
Christoph Spycher,Edward S. Miller,Kelly Townsend,Lucijana Pavic,Nicholas A. Morrice,Pavel Janscak,Grant S. Stewart,Manuel Stucki +7 more
TL;DR: The mechanism by which MDC1 physically couples the MRN complex to damaged chromatin is revealed, which disrupts the interaction between MDC2 and NBS1 and abrogates accumulation of the MRn complex at sites of DNA DSBs in vivo.
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The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks
Mayura Meerang,Danilo Ritz,Danilo Ritz,Shreya Paliwal,Zuzana Garajova,Matthias Bosshard,Niels Mailand,Pavel Janscak,Ulrich Hübscher,Hemmo Meyer,Hemmo Meyer,Kristijan Ramadan +11 more
TL;DR: Findings identify the p97–UFD1–NPL4 complex as an essential factor in ubiquitin-governed DNA-damage response, highlighting its importance in guarding genome stability.
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Human RECQ5β, a protein with DNA helicase and strand‐annealing activities in a single polypeptide
TL;DR: Surprisingly, it is found that RECQ5β possesses an intrinsic DNA strand‐annealing activity that is inhibited by RPA, the first demonstration of a DNA helicase with an intrinsic strand annealing function residing in a separate domain.