Harris Perlman

TL;DR: A fate-mapping study of the murine monocyte and macrophage compartment taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression is reported, establishing that short-lived Ly6C(+) monocytes constitute obligatory steady-state precursors of blood-resident Ly 6C(-) cells and that the abundance of Ly6 C(+) blood monocytes dynamically controls the circulation lifespan of their progeny.

TL;DR: In this paper, a fate-mapping study of the macrophage compartment is presented, taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression.

TL;DR: It is shown that mitochondrial metabolism in the absence of glucose metabolism is sufficient to support interleukin-2 (IL-2) induction and mitochondria are required for T cell activation to produce mROS for activation of nuclear factor of activated T cells (NFAT) and subsequent IL-2 induction.

TL;DR: The results support the feasibility of discovery-based approaches using next-generation sequencing technologies to identify signaling pathways for targeting in the development of personalized therapies for patients with pulmonary fibrosis.

TL;DR: Using transcriptomic profiling of flow-sorted cells, it is found that monocyte to alveolar macrophage differentiation unfolds continuously over the course of fibrosis and its resolution, and suggests that selectively targeting alveolars macrophages differentiation within the lung may ameliorate fibrosis without the adverse consequences associated with global monocyte or tissue-resident alve Polar Macrophage depletion.