R
Rajesh Narendran
Researcher at University of Pittsburgh
Publications - 71
Citations - 3479
Rajesh Narendran is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Dopamine & Amphetamine. The author has an hindex of 30, co-authored 67 publications receiving 3195 citations. Previous affiliations of Rajesh Narendran include Columbia University.
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Journal ArticleDOI
Amphetamine-Induced Dopamine Release: Markedly Blunted in Cocaine Dependence and Predictive of the Choice to Self-Administer Cocaine
Diana Martinez,Rajesh Narendran,Richard W. Foltin,Mark Slifstein,Dah-Ren Hwang,Allegra Broft,Yiyun Huang,Thomas B. Cooper,Marian W. Fischman,Herbert D. Kleber,Marc Laruelle +10 more
TL;DR: Blunted dopamine transmission in the ventral striatum and anterior caudate was predictive of the choice for cocaine over money, and this impairment appears to play a critical role in relapse.
Journal ArticleDOI
Deficits in Prefrontal Cortical and Extrastriatal Dopamine Release in Schizophrenia: A Positron Emission Tomographic Functional Magnetic Resonance Imaging Study
Mark Slifstein,Mark Slifstein,Elsmarieke van de Giessen,Elsmarieke van de Giessen,Jared X. Van Snellenberg,Jared X. Van Snellenberg,Judy L. Thompson,Judy L. Thompson,Judy L. Thompson,Rajesh Narendran,Roberto Gil,Roberto Gil,Elizabeth Hackett,Ragy R. Girgis,Ragy R. Girgis,Najate Ojeil,Holly Moore,Holly Moore,Deepak Cyril D'Souza,Robert T. Malison,Yiyun Huang,Keunpoong Lim,Nabeel Nabulsi,Richard E. Carson,Jeffrey A. Lieberman,Jeffrey A. Lieberman,Anissa Abi-Dargham,Anissa Abi-Dargham +27 more
TL;DR: These results provide the first in vivo evidence for a deficit in the capacity for dopamine release in the DLPFC in SCZ and suggest a more widespread deficit extending to many cortical and extrastriatal regions including the midbrain.
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Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo.
Rajesh Narendran,Mark Slifstein,Olivier Guillin,Yuying Hwang,Dah-Ren Hwang,Dah-Ren Hwang,Erica Scher,Stephanie Reeder,Eugenii A. Rabiner,Marc Laruelle,Marc Laruelle +10 more
TL;DR: It is concluded that [11C]PHNO is a D3 preferring agonist, and that this property explains the high GP signal not observed with [ 11C]raclopride or [11 C]NPA.
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In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride.
Rajesh Narendran,Dah Ren Hwang,Mark Slifstein,Peter S. Talbot,David Erritzoe,Yiyun Huang,Thomas B. Cooper,Diana Martinez,Lawrence S. Kegeles,Anissa Abi-Dargham,Marc Laruelle +10 more
TL;DR: Results suggest that 71% of D2 receptors are configured in a state of high affinity for agonists in vivo, and [11C]NPA might provide a superior radiotracer to probe presynaptic DA function with PET in health and disease.
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Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion.
Diana Martinez,B.A. Kaitlin Greene,Allegra Broft,Dileep Kumar,Fei Liu,Rajesh Narendran,Mark Slifstein,Ronald L. Van Heertum,Herbert D. Kleber +8 more
TL;DR: The decrease in striatal D(2)/D(3 )receptors associated with cocaine dependence cannot be attributed to higher levels of endogenous dopamine.