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Deepak Cyril D'Souza
Researcher at Yale University
Publications - 181
Citations - 9411
Deepak Cyril D'Souza is an academic researcher from Yale University. The author has contributed to research in topics: Cannabis & Psychosis. The author has an hindex of 47, co-authored 159 publications receiving 7769 citations. Previous affiliations of Deepak Cyril D'Souza include Veterans Health Administration & United States Department of Veterans Affairs.
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Journal ArticleDOI
The psychotomimetic effects of intravenous Delta-9-tetrahydrocannabinol in healthy individuals: Implications for psychosis
Deepak Cyril D'Souza,Edward Perry,Lisa MacDougall,Yola Ammerman,Thomas B. Cooper,Thomas B. Cooper,Yu-te Wu,Gabriel Braley,Ralitza Gueorguieva,John H. Krystal +9 more
TL;DR: It is indicated that Δ-9-THC produces a broad range of transient symptoms, behaviors, and cognitive deficits in healthy individuals that resemble some aspects of endogenous psychoses and warrant further study of whether brain cannabinoid receptor function contributes to the pathophysiology of psychotic disorders.
Journal ArticleDOI
Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction.
Deepak Cyril D'Souza,Walid M. Abi-Saab,Walid M. Abi-Saab,Steven Madonick,Kimberlee Forselius-Bielen,Anne Doersch,Gabriel Braley,Ralitza Gueorguieva,Thomas B. Cooper,Thomas B. Cooper,John H. Krystal +10 more
TL;DR: Delta-9-tetrahydrocannabinol is associated with transient exacerbation in core psychotic and cognitive deficits in schizophrenia, and this data do not provide a reason to explain why schizophrenia patients use or misuse cannabis.
Journal ArticleDOI
The acute effects of cannabinoids on memory in humans: a review
TL;DR: This profile of effects suggests that cannabinoids impair all stages of memory including encoding, consolidation, and retrieval, and that cannabinoids increase intrusion errors with the inhaled and intravenous route and correspond to peak drug levels.
Journal ArticleDOI
Deficits in Prefrontal Cortical and Extrastriatal Dopamine Release in Schizophrenia: A Positron Emission Tomographic Functional Magnetic Resonance Imaging Study
Mark Slifstein,Mark Slifstein,Elsmarieke van de Giessen,Elsmarieke van de Giessen,Jared X. Van Snellenberg,Jared X. Van Snellenberg,Judy L. Thompson,Judy L. Thompson,Judy L. Thompson,Rajesh Narendran,Roberto Gil,Roberto Gil,Elizabeth Hackett,Ragy R. Girgis,Ragy R. Girgis,Najate Ojeil,Holly Moore,Holly Moore,Deepak Cyril D'Souza,Robert T. Malison,Yiyun Huang,Keunpoong Lim,Nabeel Nabulsi,Richard E. Carson,Jeffrey A. Lieberman,Jeffrey A. Lieberman,Anissa Abi-Dargham,Anissa Abi-Dargham +27 more
TL;DR: These results provide the first in vivo evidence for a deficit in the capacity for dopamine release in the DLPFC in SCZ and suggest a more widespread deficit extending to many cortical and extrastriatal regions including the midbrain.
Journal ArticleDOI
Gone to Pot - A Review of the Association between Cannabis and Psychosis.
TL;DR: The evidence indicates that cannabis may be a component cause in the emergence of psychosis, and this warrants serious consideration from the point of view of public health policy.