M
Mandvi Bharadwaj
Researcher at University of Melbourne
Publications - 59
Citations - 4387
Mandvi Bharadwaj is an academic researcher from University of Melbourne. The author has contributed to research in topics: Human leukocyte antigen & Cytotoxic T cell. The author has an hindex of 28, co-authored 59 publications receiving 4089 citations. Previous affiliations of Mandvi Bharadwaj include QIMR Berghofer Medical Research Institute & Australian National University.
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Journal ArticleDOI
Immune self-reactivity triggered by drug-modified HLA-peptide repertoire
Patricia T. Illing,Julian P. Vivian,Nadine L. Dudek,Lyudmila Kostenko,Zhenjun Chen,Mandvi Bharadwaj,John J. Miles,John J. Miles,Lars Kjer-Nielsen,Stephanie Gras,Nicholas A. Williamson,Scott R. Burrows,Anthony W. Purcell,Jamie Rossjohn,Jamie Rossjohn,James McCluskey,James McCluskey +16 more
TL;DR: It is shown that unmodified abacavir binds non-covalently to HLA-B*57:01, lying across the bottom of the antigen-binding cleft and reaching into the F-pocket, where a carboxy-terminal tryptophan typically anchors peptides bound to HLAs, and that carbamazepine binds to this allotype, producing alterations in the repertoire of presented self peptides.
Journal ArticleDOI
CD1d–lipid-antigen recognition by the semi-invariant NKT T-cell receptor
Natalie A. Borg,Kwok Soon Wun,Lars Kjer-Nielsen,Matthew C.J. Wilce,Daniel G. Pellicci,Ruide Koh,Gurdyal S. Besra,Mandvi Bharadwaj,Dale I. Godfrey,James McCluskey,Jamie Rossjohn +10 more
TL;DR: The structure provides a basis for the interaction between the highly conserved NKT TCR α-chain and the CD1d–antigen complex that is typified in innate immunity, and indicates how variability of the N KT TCR β-chain can impact on recognition of other CD1D–antigens complexes.
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Ex Vivo Profiling of CD8+-T-Cell Responses to Human Cytomegalovirus Reveals Broad and Multispecific Reactivities in Healthy Virus Carriers
Rebecca Elkington,Susan Walker,Tania Crough,Moira L. Menzies,Judy Tellam,Mandvi Bharadwaj,Rajiv Khanna +6 more
TL;DR: It is found that successful HCMV-specific immune control in healthy virus carriers is dependent on a strong T-cell response towards a broad repertoire of antigens, which contrasts with previous findings that viral interference with the antigen-processing pathway during lytic infection would render immediate-early and early/late proteins less immunogenic.
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Human Leukocyte Antigen Class I-Restricted Activation of CD8+ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity
Diana Chessman,Lyudmila Kostenko,Tessa Lethborg,Anthony W. Purcell,Nicholas A. Williamson,Zhenjun Chen,Lars Kjer-Nielsen,Nicole A. Mifsud,Brian D. Tait,Rhonda Holdsworth,Coral Ann Almeida,David Nolan,W.A. Macdonald,Julia K. Archbold,Anthony D Kellerher,Deborah Marriott,Simon Mallal,Mandvi Bharadwaj,Jamie Rossjohn,James McCluskey +19 more
TL;DR: It is shown that systemic reactions to abacavir were driven by drug-specific activation of cytokine-producing, cytotoxic CD8+ T cells, suggesting a basis for the strong HLA class I-association with certain inflammatory disorders.
Journal ArticleDOI
T Cell Allorecognition via Molecular Mimicry
W.A. Macdonald,Zhenjun Chen,Stephanie Gras,Julia K. Archbold,Fleur Elizabeth Tynan,Craig Steven Clements,Mandvi Bharadwaj,Lars Kjer-Nielsen,Philippa M. Saunders,Matthew C.J. Wilce,Frances Crawford,Brian Stadinsky,David C. Jackson,Andrew G. Brooks,Anthony W. Purcell,John W. Kappler,Scott R. Burrows,Jamie Rossjohn,James McCluskey +18 more
TL;DR: Molecular mimicry that is HLA and peptide dependent is a mechanism for human T cell alloreactivity between disparate cognate and allogeneic pHLA complexes.