Rakel López de Maturana

TL;DR: Data suggest that the G2019S mutation induces autophagy via MEK/ERK pathway and that the inhibition of this exacerbated autophagic activity reduces the sensitivity observed in G 2019S mutant cells.

TL;DR: The results show that LRRK2 mutations affect α-synuclein regulation and impair NF-κB canonical signaling in iPSC-derived neurons, strengthening the link between L RRK2 and the innate immunity system underscoring the involvement of inflammatory pathways in the neurodegenerative process in PD.

TL;DR: Multiple defects in inflammatory pathways in which LRRK2 appears to be critically involved are described, including weak induction of pro-inflammatory cytokines and reduced NFκB transcriptional activation.

TL;DR: Whether iPS cell-derived neurons could be used to investigate the appearance of disease-related phenotypes (i.e, tauopathy) identified in the GSS patient is tested for the first time.

TL;DR: A novel role of PINK1 modulating the levels of L RRK2 in Parkinson’s disease fibroblasts and neurons is identified, a convergent pathway for these PARK genes is suggested, and the role of LRRK2 is broadened in the pathogenesis of Parkinson's disease.