R
Rakshita A. Charan
Researcher at University of Pennsylvania
Publications - 9
Citations - 294
Rakshita A. Charan is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Parkin & Genome-wide association study. The author has an hindex of 8, co-authored 8 publications receiving 226 citations. Previous affiliations of Rakshita A. Charan include Tata Institute of Fundamental Research & Brigham and Women's Hospital.
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Journal ArticleDOI
A Potential Role of Distinctively Delayed Blood Clearance of Recombinant Adeno-associated Virus Serotype 9 in Robust Cardiac Transduction
Nicole M. Kotchey,Kei Adachi,Maliha Zahid,Katsuya Inagaki,Rakshita A. Charan,Robert S. Parker,Hiroyuki Nakai +6 more
TL;DR: It is found that transvascular transport of rAAV9 in the heart is a capacity-limited slow process and occurs in the absence of caveolin-1, the major component of caveolae that mediate endothelial transcytosis and provides important implications in AAV capsid engineering to create new r AAV variants with more desirable properties.
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Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin
TL;DR: The data suggest that regulation of apoptosis by the inhibition of Bax translocation is a prevalent physiological function of parkin regardless of the kind of cell stress, preventing overt cell death and supporting cell viability during mitochondrial injury and repair.
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Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes
Johanna I. Busch,Travis L. Unger,Nimansha Jain,R. Tyler Skrinak,Rakshita A. Charan,Alice Chen-Plotkin +5 more
TL;DR: It is reported that increased TMEM106B expression results in the appearance of a vacuolar phenotype in multiple cell types, including neurons, and it is demonstrated that abrogation of sorting to lysosomes rescues TMEM 106B-induced defects.
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GPNMB confers risk for Parkinson’s disease through interaction with α-synuclein
Maria Diaz-Ortiz,Yunji Seo,Marijan Posavi,Marc Carceles Cordon,Elisia M. Clark,Nimansha Jain,Rakshita A. Charan,Michael Gallagher,Travis L. Unger,Noor Amari,R. Tyler Skrinak,Roseanne Davila-Rivera,Eliza M. Brody,N. Han,Rebecca Zack,Vivianna M. Van Deerlin,Thomas F. Tropea,Kelvin C. Luk,Edward B. Lee,Daniel Weintraub,Alice Chen-Plotkin +20 more
TL;DR: The GWAS-derived chromosome 7 locus (sentinel single-nucleotide polymorphism rs199347) is linked to GPNMB through colocalization analyses of expression quantitative trait locus and PD risk signals, confirmed by allele-specific expression studies in the human brain.
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Pathologic and therapeutic implications for the cell biology of parkin.
TL;DR: The various pathways in which parkin acts and the mechanisms byWhich parkin may be targeted for therapeutic intervention are described.