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Vivianna M. Van Deerlin

Researcher at University of Pennsylvania

Publications -  288
Citations -  31517

Vivianna M. Van Deerlin is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Frontotemporal lobar degeneration & Frontotemporal dementia. The author has an hindex of 85, co-authored 262 publications receiving 26035 citations. Previous affiliations of Vivianna M. Van Deerlin include National Institutes of Health & Harvard University.

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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Adam C. Naj, +156 more
- 01 May 2011 - 
TL;DR: The Alzheimer Disease Genetics Consortium performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1), two replication stages (stages 2 and 3), and both joint analysis and meta-analysis approaches were used.
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Analysis of shared heritability in common disorders of the brain

Verneri Anttila, +720 more
- 22 Jun 2018 - 
TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
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Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

Andrew Elden, +22 more
- 26 Aug 2010 - 
TL;DR: It is shown that ataxin 2 (ATXN2), a polyglutamine (polyQ) protein mutated in spinocerebellar ataxia type 2, is a potent modifier of TDP-43 toxicity in animal and cellular models.
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Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

Janel O. Johnson, +39 more
- 09 Dec 2010 - 
TL;DR: Exome sequencing data broaden the phenotype of IBMPFD to include motor neuron degeneration, suggest that VCP mutations may account for ∼1%-2% of familial ALS, and provide evidence directly implicating defects in the ubiquitination/protein degradation pathway in motor neurons degeneration.
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Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

Elisa Majounie, +71 more
- 01 Apr 2012 - 
TL;DR: A common Mendelian genetic lesion in C9orf72 is implicated in many cases of sporadic and familial ALS and FTD, suggesting a one-off expansion occurring about 1500 years ago.